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Table 2 The baseline characteristics of 316 AML patients

From: Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML)

Characteristics

Totality, n (%)

Median (range)

Gender

361

 

 Male

196 (54.3%)

 

 Female

165 (45.7%)

 

Age

361

43 (16–76) years

FAB classification

 M1

19 (5.3%)

 

 M2

193 (53.5%)

 

 M4

63 (17.5%)

 

 M5

75 (20.8%)

 

 M6

6 (1.7%)

 

 Undefined

5 (1.4%)

 

WBC

356 (98.6%)

14.7 (0.4–426.0), × 109/L

LDH

341 (94.5%)

363 (17–5853), U/L

BM blast %

348 (96.4%)

71% (17–99%)

RBC

356 (98.6%)

2.19 (0.67–4.98), × 1012/L

Hemoglobin

356 (98.6%)

72 (27–149), g/L

Platelets

356 (98.6%)

34 (2–546), × 109/L

Neutrophil

356 (98.6%)

2.2 (0.0–340.3), × 109/L

Risk stratifications

 Low risk

71 (19.7%)

 

 Intermediate risk

187 (51.8%)

 

 High risk

78 (21.6%)

 

 Undefined

25 (6.9%)

 

FLT3-ITD mutation

 Positive

42 (11.6%)

 

 Negative

294 (81.4%)

 

 Unknown

25 (6.9%)

 

NPM1 mutation

 Positive

67 (18.6%)

 

 Negative

269 (74.5%)

 

 Unknown

25 (6.9%)

 

CEBPA mutation

 Positive

50 (13.9%)

 

 Negative

286 (79.2%)

 

 Unknown

25 (6.9%)

 

Karyotype

 Normal

255 (70.6%)

 

 Abnormal

84 (23.3%)

 

 Unknown

22 (6.1%)

 

Allo-HCT

 Yes

64 (17.7%)

 

 No

297 (82.3%)

 

CR after two courses of induction therapy

 Yes

205 (56.8%)

 

 No

120 (33.2%)

 

 Not evaluated

36 (10.0%)

 

Chemotherapy regimens

 MA

125 (34.6%)

 

 IA

86 (23.8%)

 

 TA

47 (13.0%)

 

 DA

31 (8.6%)

 

 CAG

52 (14.4%)

 

 Other regimens

20 (5.5%)

 
  1. FAB French–Britain–American, WBC white blood cell, LDH lactate dehydrogenase, BM bone marrow, RBC red blood cell, Allo-SCT allogeneic hematopoietic stem cell transplantation, CR complete remission, THP pirarubicin, MA Ara-C + mitoxantrone, IA Ara-C + idarubicin, TA Ara-C + THP, DA Ara-C + daunorubicin, CAG Ara-C + aclarubicin + G-CSF