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Table 4 Review all the studies concerning mutational analysis of primary PEACs

From: Distinctive features of immunostaining and mutational load in primary pulmonary enteric adenocarcinoma: implications for differential diagnosis and immunotherapy

Study No. of cases Gene mutation
KARS exon2-4 EGFR exon 18-21 EML4-ALK BRAF exon15 NRAS exon2-4 ERBB2 (HER2) amplification/mutation MMR
Stojsic et al. [16] 2 1+/1− 2− NA NA NA NA NA
Lászlo et al. [17] 1 1+ 1− NA NA NA NA NA
Garajová et al. [18] 2 2+ 2− 2− NA NA NA NA
Metro et al. [19] 1 1+ NA NA NA NA NA NA
Lin et al. [21] 1 1− 1− 1− 1− NA NA NA
Wang et al. [15] 9 9− 9− 9− NA NA NA NA
Handa et al. [20] 1 NA 1+ NA NA NA NA NA
Nottegar et al. [4] 46 28+/18− 1+/45− 6+/40- 46− NA NA NA
Matsushima et al. [22] 7 1+/6− 7− NA 7− NA NA NA
Nottegar et al. [5] 8 4+/4− 8− 1+/7− 8− 8− NA NA
The present study 5 1+/4− 1+/4− 5− 5− 1+/4− 2+/3− 4+/1−
Total 39+/43− 3+/79− 7+/64− 67− 1+/12− 2+/3− 4+/1−
Incidence of mutation (%) 47.6 3.7 9.9 0 7.7 40 80
  1. The studies concerning sensitivity genes mutation in primary PEAC that published since 1991 were reviewed. Our results from targeted exome sequencing of 315 CGPs in five classic samples of primary PEAC were also showed