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Table 2 Review all the studies concerning IHC markers of primary PEACs

From: Distinctive features of immunostaining and mutational load in primary pulmonary enteric adenocarcinoma: implications for differential diagnosis and immunotherapy

Study No. of cases Immunohistochemical results
CK-7 TTF-1 CK-20 CDX2
Yousem [8] 6 6+ 6+ 6− 6−
Inamura et al. [9] 7 7+ 3+/4− 3+/4− 5+/2−
Li et al. [10] 1 1− 1− 1+ 1+
Hatanaka et al. [11] 1 1− 1− 1+ 1+
Maeda et al. [12] 1 1+ 1+ 1− NA
Lin et al. [13] 1 1+ 1− 1+ 1−
Qureshi et al. [14] 1 1+ 1− 1+ 1+
Wang et al. [15] 9 9+ 4+/5− 2+/7− 6+/3−
Stojsic et al. [16] 2 2− 2− 2+ 2+
Laszlo et al. [17] 1 1− 1− 1+ 1+
Garajová et al. [18] 2 1+/1− 2− 1+/1− 2+
Metro et al. [19] 1 1+ 1− 1− 1+
Handa et al. [20] 1 1+ 1+ 1− 1−
Nottegar et al. [4] 46 46+ 21+/25− 15+/31− 46+
Lin et al. [21] 1 1− 1− 1+ 1+
Matsushima et al. [22] 8 7+/1− 1+/7− 7+/1− 5+/3−
Nottegar et al. [5] 8 8+ 1+/7− 1+/7− 8+
Sun et al. [23] 1 1+ 1− 1− 1+
Bian et al. [24] 13 10+/3− 7+/6− 8+/5− 8+/5−
The present study 18 16+/2− 7+/11− 17+/1− 13+/5−
Total 129 116+/13− 52+/77− 62+/67− 102+/26−
Positive expression (%) 89.9 40.3 48.1 79.1
  1. The studies concerning immunohistochemical analysis of primary PEAC that published since 1991 were retrospectively reviewed. The information of CDX2, CK20, CK7 and TTF-1 expression in these studies was collected and their rates of positive expression were computed
  2. IHC immunohistochemical, TTF-1 thyroid transcription factor 1, CK cytokeratin, CDX2 caudal type homeobox 2, NA not available