Fig. 3

Primary PEACs harbored a high incidence of MMR genes mutation and higher TMB compared with usual PACs. a 4/5 primary PEAC patients harbored MMR genes mutation and the mutation frequency of core MMR genes (MLH1, PMS2, MSH2 and MSH6) and the TMB (muts/Mb) of each patient was showed. b The TMB of primary PEACs (mean: 80.0 ± 20.1 muts/Mb, N = 5) was significantly higher than that of usual PACs (mean: 9.5 ± 2.9 muts/Mb, N = 3) (t = − 2.627, P (2-tailed) = 0.039, P < 0.05)