HNA-3a and HNA-3b antigens among 9 ethnic populations and the Han population in Southwest China

Table 1 SLC44A2 allele distribution and HNA-3 antigens predicted by genotype

Blood donors					Genotypes			SLC44A2 allele frequency		Hardy–Weinberg		Chance of being exposed to an alloimmunization risk against HNA-3a
Population group	Ethnicity	Location	Province	n	HNA-3a/a	HNA-3a/b	HNA-3b/b	HNA-3a	HNA-3b	χ²	P
Minority	Yi	Honghe	Yunnan	120	61 (51%)	53 (44%)	6 (5%)^a	0.73	0.27^b,c	1.67	0.2	0.068
		Chuxiong	Yunnan	153	82 (54%)	58 (38%)	13 (8%)^a	0.73	0.27^b,c	0.36	0.55	0.068
		Luquan	Yunnan	122	55 (45%)	56 (46%)	11 (9%)^a	0.68	0.32^d	0.37	0.54	0.092
		Shilin	Yunnan	83	39 (47%)	33 (40%)	11 (13%)	0.67	0.33^d	0.88	0.35	0.097
		Xichang	Sichuan	144	57 (40%)	59 (41%)	28 (19%)	0.60	0.40	3.06	0.08	0.134
	Zhuang	Wenshan	Yunnan	196	115 (59%)	69 (35%)	12 (6%)^a	0.76	0.24^b,c	0.15	0.70	0.054
	Derung	Nujiang	Yunnan	184	107 (58%)	62 (34%)	15 (8%)^a	0.75	0.25^b,c	1.89	0.17	0.059
	Hani	Honghe	Yunnan	190	119 (63%)	59 (31%)	12 (6%)^a	0.78	0.22	1.56	0.21	0.046
	Lisu	Lijiang	Yunnan	254	146 (57%)	87 (34%)	21 (8%)^a	0.75	0.25^b,c	2.34	0.13	0.059
	Bai	Dali	Yunnan	190	95 (50%)	79 (42%)	16 (8%)^a	0.71	0.29	0.01	0.94	0.077
	Miao	Wenshan	Yunnan	209	101 (48%)	90 (43%)	18 (9%)^a	0.70	0.30^d	0.11	0.74	0.082
	Dai	Xishuangbanna	Yunnan	126	62 (49%)	51 (40%)	13 (10%)	0.69	0.31	0.27	0.60	0.087
	Naxi	Lijiang	Yunnan	187	85 (45%)	86 (46%)	16 (9%)^a	0.68	0.32	0.78	0.38	0.092
Majority	Han	Yunnan	Yunnan	192	67 (35%)	102 (53%)	23 (12%)	0.61	0.39^d	2.83	0.09	0.129
	Han	Sichuan	Sichuan	232	94 (41%)	113 (49%)	25 (11%)	0.65	0.35	1.09	0.30	0.107

Differences were significant when P < 0.05
^aThe genotype frequency significantly differs compared to Sichuan Yi (Chi square test)
^bThe allele frequency significantly differs compared to Sichuan Yi (Chi square test)
^cThe allele frequency significantly differs compared to Sichuan Han (Chi square test)
^dThe allele frequency significantly differs compared to Yunnan Zhuang (Chi square test)

ISSN: 1479-5876