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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation

Fig. 6

γ-secretase inhibitor DAPT inhibits the expression of RORγt mRNA. a RORγt mRNA expression in splenic single-cell suspension was significantly elevated in IMQ-treated mice compared to control mice (#P < 0.01), while it was obviously decreased in IMQ + DAPT-treated mice (#P < 0.01). b After DAPT treatment and Th17-cell polarization in vitro, RORγt mRNA expression was significantly decreased with the increased dose of DAPT in splenic CD4+ T cells of IMQ-treated mice (#P < 0.01)

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