Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease

Table 1 Demographic characteristics and pulmonary function test parameters of the 40 COPD patients and 16 healthy non-smokers

	Healthy non-smokers N = 16	COPD patients at diagnosis N = 40	p value	COPD patients followed up after 1-year treatment N = 10
Age, years	53.9 ± 12.2	63.4 ± 4.5	0.009	69.5 ± 9.5
BMI, kg/m²	25.38 ± 4.6	25 ± 4.2	0.775	24.6 ± 4.6
Smoking exposure, pack-years	0	64.4 ± 40.1	< 0.001	65.5 ± 50.8
Ex-smokers, n (%)		21 (52.2)		7 (70%)
Diabetes mellitus, n (%)	1 (6.3)	5 (12.8)	0.478
Stroke, n (%)	0 (0)	2 (5.1)	0.356
Chronic hepatitis, n (%)	1 (6.3)	5 (12.8)	0.478
Chronic kidney disease, n (%)	0 (0)	5 (12.8)	0.133
Congestive heart failure, n (%)	0 (0)	0 (0)	1
Myocardial infarction, n (%)	0 (0)	0 (0)	1
MMRC score	0.38 ± 0.5	1.49 ± 0.99	< 0.001	1.2 ± 0.79
HbA1c	5.8 ± 0.5	5.9 ± 0.6	0.663	6.0 ± 0.8
Triglyceride	105.7 ± 60.4	119.7 ± 50.2	0.389	146.3 ± 82.7
Cholesterol	187.9 ± 44.4	185.7 ± 36.6	0.853	184.4 ± 38.5
Pre-BD FEV1 %predicted, %	113.18 ± 16.1	57.72 ± 24.56	< 0.001	56.74 ± 12.96
Pre-BD FEV1/FVC, %	81.56 ± 5.4	54.44 ± 15.38	< 0.001	55.03 ± 10.27
Pre-BD FEF25-75%, %predicted	109.6 ± 27.1	26.2 ± 20.4	< 0.001	21.28 ± 9.63
Post-BD FEV1, %predicted	N.A.	61.68 ± 22.68		61.7 ± 13.28
Post-BD FEV1/FVC, %	N.A.	57.1 ± 13.1		56.74 ± 11.27
Post-BD FEF25–75%, %predicted	N.A.	28.8 ± 17.8		25.37 ± 11.14

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