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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells

Fig. 4

Effect of RTK ligands on phagocytosis in human RPE from donor eyes with AMD. The human RPE cells isolated from eyes of 4 AMD donors with age 65, 84, 86, and 88 were incubated with recombinant human BDNF (a), HGF (b), or GDNF (c) for 24 h, and then subjected to phagocytosis assay. The human RPE incubated with the hUTC CM was used as a positive control for the assay. Normal RPE cells from eyes of donors without ocular diseases, AMD RPE cells from eyes of donors with AMD, CM conditioned medium. Data represent the mean ± SEM (n = 4). ****P < 0.0001. Representative images of RPE containing fluorescent ingested POS are shown (scale bar = 10 µm)

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