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Table 2 Metabolic characteristics of swine show hyperlipidemia and hyperglycemia in the MetS/D-A group

From: Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

  Lean MetS MetS-A MetS/D-A
Body weight at sacrifice (kg) 48 ± 2 87 ± 5* 73 ± 1*, 70 ± 4*,
Age at sacrifice (mo) 17 ± 1.4 15 ± 0.7 11 ± 0.2 14 ± 0.1
% Male 37.5 50 50 50
Creatinine (mg/dL) 0.96 ± 0.05 1.26 ± 0.13* 1.14 ± 0.07 1.06 ± 0.10
BUN (mg/dL) 14.33 ± 1.44 12.11 ± 1.65 15.00 ± 0.98 16.75 ± 0.96
AST/ALT ratio 0.95 ± 0.08 1.43 ± 0.30 1.29 ± 0.14 2.12 ± 0.49*
Serum calcium (mg/dL) 10.4 ± 0.1 10.6 ± 0.1 10.1 ± 0.1 10.3 ± 0.2
Serum phosphorous (mg/dL) 8.1 ± 0.6 7.0 ± 0.3 12.9 ± 0.7*, 11.6 ± 0.7*,
Total chol (mg/dL) 87 ± 3 398 ± 1* 547 ± 109*, 1005 ± 158*,,
Serum TG (mg/dL) 29 ± 3 42 ± 4 40 ± 6 236 ± 96*,
  1. All measurements were taken 6 months after atherogenic diet (except lean swine) and 1 week before euthanasia
  2. Data are mean ± SEM. MetS metabolic syndrome, MetS-A metabolic syndrome-alloxan, MetS/D-A metabolic syndrome with diabetes-alloxan, BUN, blood urea nitrogen, AST aspartate transaminase, ALT alanine transaminase, bG blood glucose, Chol cholesterol, TG triglycerides
  3. *p < 0.05 compared with lean swine; p < 0.05 compared with MetS swine; p < 0.05 compared with MetS-A swine. (Lean = 9; MetS = 10; MetS-A = 8; MetS/D-A = 8.)