Skip to main content

Table 2 Metabolic characteristics of swine show hyperlipidemia and hyperglycemia in the MetS/D-A group

From: Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

 

Lean

MetS

MetS-A

MetS/D-A

Body weight at sacrifice (kg)

48 ± 2

87 ± 5*

73 ± 1*,†

70 ± 4*,†

Age at sacrifice (mo)

17 ± 1.4

15 ± 0.7

11 ± 0.2

14 ± 0.1

% Male

37.5

50

50

50

Creatinine (mg/dL)

0.96 ± 0.05

1.26 ± 0.13*

1.14 ± 0.07

1.06 ± 0.10

BUN (mg/dL)

14.33 ± 1.44

12.11 ± 1.65

15.00 ± 0.98

16.75 ± 0.96

AST/ALT ratio

0.95 ± 0.08

1.43 ± 0.30

1.29 ± 0.14

2.12 ± 0.49*

Serum calcium (mg/dL)

10.4 ± 0.1

10.6 ± 0.1

10.1 ± 0.1

10.3 ± 0.2

Serum phosphorous (mg/dL)

8.1 ± 0.6

7.0 ± 0.3

12.9 ± 0.7*,†

11.6 ± 0.7*,†

Total chol (mg/dL)

87 ± 3

398 ± 1*

547 ± 109*,†

1005 ± 158*,†,‡

Serum TG (mg/dL)

29 ± 3

42 ± 4

40 ± 6

236 ± 96*†,‡

  1. All measurements were taken 6 months after atherogenic diet (except lean swine) and 1 week before euthanasia
  2. Data are mean ± SEM. MetS metabolic syndrome, MetS-A metabolic syndrome-alloxan, MetS/D-A metabolic syndrome with diabetes-alloxan, BUN, blood urea nitrogen, AST aspartate transaminase, ALT alanine transaminase, bG blood glucose, Chol cholesterol, TG triglycerides
  3. *p < 0.05 compared with lean swine; †p < 0.05 compared with MetS swine; ‡p < 0.05 compared with MetS-A swine. (Lean = 9; MetS = 10; MetS-A = 8; MetS/D-A = 8.)