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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

Fig. 6

MetS/D-A swine showed greater spotty calcification compared to lean swine and MetS-A swine. a Representative IVUS image from the proximal LAD of a MetS/D-A swine. IVUS images were analyzed for calcification severity by using the calcium index measurement. The lumen is outlined in red, with the arc of spotty calcification and acoustic shadowing outlined in yellow. b Representative Von Kossa-stained histological section from the proximal LAD of a MetS/D-A swine, with noticeable spotty calcification in the neointimal layer (blue arrows). c Calcium index is higher in MetS/D-A swine as compared to lean and MetS-A swine. d Findings from analysis of IVUS data correlate to the Von Kossa histological staining analysis. *p < 0.05 compared with lean swine; p < 0.05 compared with MetS-A swine. (Lean = 6; MetS-A = 7; MetS/D-A = 7.)

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