Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome

Table 5 Pathways significantly enriched for the identified protein coding genes in the blood of patients with MFS compared to HV controls (adjusted P value < 0.05)

PANTHER classification pathways	Number of genes			Over-/under-represented (±)	Fold enrichment	P value
PANTHER classification pathways	Reference list^a	Target list^b	Expected^c	Over-/under-represented (±)	Fold enrichment	P value
Apoptosis signaling pathway (P00006)	119	10	1.68	+	5.96	0.00154
JAK/STAT signaling pathway (P00038)	17	4	0.24	+	16.69	0.00210
Integrin signalling pathway (P00034)	194	11	2.73	+	4.02	0.01920
Angiogenesis (P00005)	174	10	2.45	+	4.08	0.03500

Pathways resulted significantly over-represented by the identified protein coding genes. P values were tested using Fisher exact test and adjusted using a Bonferroni correction test. MFS Marfan syndrome, HVs healthy volunteers
^a Number of genes in the reference list that map to this PANTHER classification category
^b Number of genes in the target genes list that map to this PANTHER classification category
^c Expected value is the number of genes that could be expected in target genes list for this PANTHER category based on the reference list

ISSN: 1479-5876