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Table 4 Correlation between clinical parameters and validated miRNA and mRNA expression levels by RT-qPCR in patients with MFS P < 0.05)

From: Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome

Parameters Marfan syndrome patients Healthy volunteers
Age (MFS patients) Aortic root status
(Z score)
LVEDD MVP Age
miRNA Correlation P value Correlation P value Correlation P value P value* Correlation P value
hsa-miR-1234 0.003 0.988 0.063 0.761 − 0.075 0.716 0.732 − 0.122 0.554
hsa-miR-151-5p 0.519 0.007 0.375 0.059 0.496 0.010 0.979 0.055 0.789
hsa-miR-200c 0.370 0.063 0.473 0.015 0.213 0.295 0.060 − 0.220 0.279
hsa-miR-24 0.496 0.010 0.281 0.164 0.420 0.033 0.654 − 0.194 0.342
hsa-miR-30e 0.565 0.003 0.230 0.258 0.472 0.015 0.517 − 0.030 0.883
hsa-miR-324-5p 0.510 0.008 0.350 0.079 0.457 0.019 0.391 − 0.019 0.927
hsa-miR-362-5p 0.413 0.036 0.216 0.289 0.383 0.053 0.673 0.024 0.906
hsa-miR-500b 0.440 0.024 0.384 0.053 0.456 0.019 0.812 − 0.003 0.987
hsa-miR-502-3p 0.505 0.008 0.260 0.200 0.425 0.030 0.816 0.036 0.860
hsa-miR-627 0.310 0.123 0.291 0.149 0.423 0.032 0.816 0.010 0.961
hsa-miR-331-3p 0.307 0.127 0.333 0.097 0.015 0.942 0.041 − 0.243 0.231
Parameters Marfan syndrome patients Healthy volunteers
Age Aortic root status
(Z score)
LVEDD MVP Age
mRNA Correlation P value Correlation P value Correlation P value P value Correlation P value
DYSF 0.123 0.550 0.087 0.672 − 0.010 0.963 0.958 0.186 0.385
GBP2 0.200 0.326 0.071 0.729 − 0.198 0.332 0.816 0.080 0.710
LIMK2 0.003 0.989 − 0.142 0.489 − 0.241 0.235 0.916 0.135 0.530
MMP9 0.276 0.173 0.272 0.178 − 0.042 0.840 0.460 0.295 0.162
MX1 0.071 0.732 − 0.142 0.489 0.019 0.926 0.897 0.073 0.736
POT1 − 0.028 0.891 − 0.041 0.842 − 0.306 0.129 0.510 − 0.075 0.727
  1. LVEDD left ventricular end diastolic diameter, MVP mitral valve prolapse. P values were calculated using unpaired-two-tailed t test (P < 0.05). *P values were calculated using Wilcoxon test (P < 0.05)
  2. Italic—significant with adjusted P-value
  3. Bold Italic—borderline significant with adjusted P-value