Journal of Translational Medicine

Table 4 Correlation between clinical parameters and validated miRNA and mRNA expression levels by RT-qPCR in patients with MFS P < 0.05)

From: Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome

Parameters	Marfan syndrome patients							Healthy volunteers
Parameters	Age (MFS patients)		Aortic root status (Z score)		LVEDD		MVP	Age
miRNA	Correlation	P value	Correlation	P value	Correlation	P value	P value*	Correlation	P value
hsa-miR-1234	0.003	0.988	0.063	0.761	− 0.075	0.716	0.732	− 0.122	0.554
hsa-miR-151-5p	0.519	0.007	0.375	*0.059*	0.496	0.010	0.979	0.055	0.789
hsa-miR-200c	0.370	*0.063*	0.473	0.015	0.213	0.295	0.060	− 0.220	0.279
hsa-miR-24	0.496	0.010	0.281	0.164	0.420	0.033	0.654	− 0.194	0.342
hsa-miR-30e	0.565	0.003	0.230	0.258	0.472	0.015	0.517	− 0.030	0.883
hsa-miR-324-5p	0.510	0.008	0.350	*0.079*	0.457	0.019	0.391	− 0.019	0.927
hsa-miR-362-5p	0.413	0.036	0.216	0.289	0.383	*0.053*	0.673	0.024	0.906
hsa-miR-500b	0.440	0.024	0.384	*0.053*	0.456	0.019	0.812	− 0.003	0.987
hsa-miR-502-3p	0.505	0.008	0.260	0.200	0.425	0.030	0.816	0.036	0.860
hsa-miR-627	0.310	0.123	0.291	0.149	0.423	0.032	0.816	0.010	0.961
hsa-miR-331-3p	0.307	0.127	0.333	0.097	0.015	0.942	0.041	− 0.243	0.231

Parameters	Marfan syndrome patients							Healthy volunteers
Parameters	Age		Aortic root status (Z score)		LVEDD		MVP	Age
mRNA	Correlation	P value	Correlation	P value	Correlation	P value	P value	Correlation	P value
DYSF	0.123	0.550	0.087	0.672	− 0.010	0.963	0.958	0.186	0.385
GBP2	0.200	0.326	0.071	0.729	− 0.198	0.332	0.816	0.080	0.710
LIMK2	0.003	0.989	− 0.142	0.489	− 0.241	0.235	0.916	0.135	0.530
MMP9	0.276	0.173	0.272	0.178	− 0.042	0.840	0.460	0.295	0.162
MX1	0.071	0.732	− 0.142	0.489	0.019	0.926	0.897	0.073	0.736
POT1	− 0.028	0.891	− 0.041	0.842	− 0.306	0.129	0.510	− 0.075	0.727

LVEDD left ventricular end diastolic diameter, MVP mitral valve prolapse. P values were calculated using unpaired-two-tailed t test (P < 0.05). *P values were calculated using Wilcoxon test (P < 0.05)
Italic—significant with adjusted P-value
Bold Italic—borderline significant with adjusted P-value

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