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Table 2 Significantly expressed protein coding genes in the blood of patients with MFS (n = 7) compared HVs controls (n = 7) as determined by microarray (unpaired two-tailed t test. > 2.0-fold difference. P < 0.05)

From: Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome

Gene Name

NCBI accession code

Median log2 MFS

Median log2 HVS

Fold change

log2 Fold change

Regulation

P value

AUC

POT1 (protection of telomeres 1)

NM_015450

7.96

9.05

0.47

−1.09

Down

0.0002

1.00

SIRPB1 (signal regulatory protein beta 1)

NM_001135844

11.30

8.96

5.08

2.34

Up

0.0474

0.16

HBZ (hemoglobin subunit zeta)

NM_005332

8.71

6.47

4.73

2.24

Up

0.0132

0.16

MYOM2 (myomesin 2)

NM_003970

8.38

6.50

3.67

1.87

Up

0.0372

0.14

ITGB3 (integrin subunit beta 3)

NM_000212

9.23

7.38

3.62

1.86

Up

0.0392

0.08

MX1 (MX dynamin like GTPase 1)

NM_002462

12.89

11.36

2.89

1.53

Up

0.0383

0.16

DYSF (dysferlin)

NM_003494

10.49

9.04

2.74

1.45

Up

0.0149

0.08

CCR1 (C-C motif chemokine receptor 1)

NM_001295

12.91

11.50

2.66

1.41

Up

0.0217

0.12

IFIT2 (interferon induced protein with tetratricopeptide repeats 2)

NM_001547

11.56

11.33

1.17

0.23

Up

0.0317

0.14

LRG1 (leucine rich alpha-2-glycoprotein 1)

NM_052972

11.14

9.85

2.45

1.29

Up

0.0181

0.16

TRANK1 (tetratricopeptide repeat and ankyrin repeat containing 1)

NM_014831

10.86

9.62

2.37

1.25

Up

0.0013

0.02

ZAN (zonadhesin (gene/pseudogene))

NM_173059

9.30

8.08

2.34

1.23

Up

0.0423

0.18

CRYAA (crystallin alpha A)

NM_000394

9.30

8.08

2.34

1.23

Up

0.0329

0.18

NRGN (neurogranin)

NM_006176

12.69

11.52

2.25

1.17

Up

0.0356

0.12

RNF213 (ring finger protein 213)

NM_020914

8.24

7.70

1.46

0.55

Up

0.0377

0.18

LIMK2 (LIM domain kinase 2)

NM_001031801

9.31

8.16

2.22

1.15

Up

0.0181

0.14

MFN2 (mitofusin 2)

NM_014874

5.49

5.18

1.24

0.31

Up

0.0288

0.20

CTTN (cortactin)

NM_005231

9.51

8.36

2.21

1.14

Up

0.0268

0.16

MX2 (MX dynamin like GTPase 2)

NM_002463

12.60

11.52

2.11

1.07

Up

0.0157

0.12

CD14 (CD14 molecule)

NM_001174104

15.04

13.97

2.10

1.07

Up

0.0332

0.16

GRN (granulin precursor)

NM_002087

15.83

14.76

2.10

1.07

Up

0.0258

0.16

RNF222 (ring finger protein 222)

NM_001146684

5.29

5.01

1.22

0.28

Up

0.0336

0.14

MVP (major vault protein)

NM_017458

14.55

13.49

2.08

1.06

Up

0.0046

0.08

CXCL5 (C-X-C motif chemokine ligand 5)

NM_002994

8.88

7.83

2.07

1.05

Up

0.0455

0.18

CTNNA1 (catenin alpha 1)

NM_001903

9.08

8.05

2.05

1.04

Up

0.0309

0.16

MMP9 (matrix metallopeptidase 9)

NM_004994

13.20

12.14

2.07

1.05

Up

0.0456

0.20

SOCS3 (suppressor of cytokine signaling 3)

NM_003955

9.47

8.43

2.05

1.03

Up

0.0472

0.20

GBP2 (guanylate binding protein 2)

NM_004120

11.49

10.46

2.04

1.03

Up

0.0097

0.08

GNL3L (G protein nucleolar 3 like)

NM_019067

8.33

7.93

1.32

0.41

Up

0.0325

0.20

CLU (clusterin)

NM_001831

9.71

8.69

2.02

1.02

Up

0.0423

0.22

SELL (selectin L)

NM_000655

14.93

13.93

2.00

1.00

Up

0.0011

0.04

OSM (oncostatin M)

NM_020530

9.18

8.19

2.00

1.00

Up

0.0414

0.14

  1. Each value represents the median of 7 MFS patients and 7 HV controls and ± standard deviation (STDV). Statistical analysis was performed with unpaired-two-tailed t test (P < 0.05). MFS Marfan syndrome, HVs healthy volunteers; AUC area under the receiver operating characteristic curve