Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Significantly expressed protein coding genes in the blood of patients with MFS (n = 7) compared HVs controls (n = 7) as determined by microarray (unpaired two-tailed t test. > 2.0-fold difference. P < 0.05)

From: Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome

Gene Name NCBI accession code Median log2 MFS Median log2 HVS Fold change log2 Fold change Regulation P value AUC
POT1 (protection of telomeres 1) NM_015450 7.96 9.05 0.47 −1.09 Down 0.0002 1.00
SIRPB1 (signal regulatory protein beta 1) NM_001135844 11.30 8.96 5.08 2.34 Up 0.0474 0.16
HBZ (hemoglobin subunit zeta) NM_005332 8.71 6.47 4.73 2.24 Up 0.0132 0.16
MYOM2 (myomesin 2) NM_003970 8.38 6.50 3.67 1.87 Up 0.0372 0.14
ITGB3 (integrin subunit beta 3) NM_000212 9.23 7.38 3.62 1.86 Up 0.0392 0.08
MX1 (MX dynamin like GTPase 1) NM_002462 12.89 11.36 2.89 1.53 Up 0.0383 0.16
DYSF (dysferlin) NM_003494 10.49 9.04 2.74 1.45 Up 0.0149 0.08
CCR1 (C-C motif chemokine receptor 1) NM_001295 12.91 11.50 2.66 1.41 Up 0.0217 0.12
IFIT2 (interferon induced protein with tetratricopeptide repeats 2) NM_001547 11.56 11.33 1.17 0.23 Up 0.0317 0.14
LRG1 (leucine rich alpha-2-glycoprotein 1) NM_052972 11.14 9.85 2.45 1.29 Up 0.0181 0.16
TRANK1 (tetratricopeptide repeat and ankyrin repeat containing 1) NM_014831 10.86 9.62 2.37 1.25 Up 0.0013 0.02
ZAN (zonadhesin (gene/pseudogene)) NM_173059 9.30 8.08 2.34 1.23 Up 0.0423 0.18
CRYAA (crystallin alpha A) NM_000394 9.30 8.08 2.34 1.23 Up 0.0329 0.18
NRGN (neurogranin) NM_006176 12.69 11.52 2.25 1.17 Up 0.0356 0.12
RNF213 (ring finger protein 213) NM_020914 8.24 7.70 1.46 0.55 Up 0.0377 0.18
LIMK2 (LIM domain kinase 2) NM_001031801 9.31 8.16 2.22 1.15 Up 0.0181 0.14
MFN2 (mitofusin 2) NM_014874 5.49 5.18 1.24 0.31 Up 0.0288 0.20
CTTN (cortactin) NM_005231 9.51 8.36 2.21 1.14 Up 0.0268 0.16
MX2 (MX dynamin like GTPase 2) NM_002463 12.60 11.52 2.11 1.07 Up 0.0157 0.12
CD14 (CD14 molecule) NM_001174104 15.04 13.97 2.10 1.07 Up 0.0332 0.16
GRN (granulin precursor) NM_002087 15.83 14.76 2.10 1.07 Up 0.0258 0.16
RNF222 (ring finger protein 222) NM_001146684 5.29 5.01 1.22 0.28 Up 0.0336 0.14
MVP (major vault protein) NM_017458 14.55 13.49 2.08 1.06 Up 0.0046 0.08
CXCL5 (C-X-C motif chemokine ligand 5) NM_002994 8.88 7.83 2.07 1.05 Up 0.0455 0.18
CTNNA1 (catenin alpha 1) NM_001903 9.08 8.05 2.05 1.04 Up 0.0309 0.16
MMP9 (matrix metallopeptidase 9) NM_004994 13.20 12.14 2.07 1.05 Up 0.0456 0.20
SOCS3 (suppressor of cytokine signaling 3) NM_003955 9.47 8.43 2.05 1.03 Up 0.0472 0.20
GBP2 (guanylate binding protein 2) NM_004120 11.49 10.46 2.04 1.03 Up 0.0097 0.08
GNL3L (G protein nucleolar 3 like) NM_019067 8.33 7.93 1.32 0.41 Up 0.0325 0.20
CLU (clusterin) NM_001831 9.71 8.69 2.02 1.02 Up 0.0423 0.22
SELL (selectin L) NM_000655 14.93 13.93 2.00 1.00 Up 0.0011 0.04
OSM (oncostatin M) NM_020530 9.18 8.19 2.00 1.00 Up 0.0414 0.14
  1. Each value represents the median of 7 MFS patients and 7 HV controls and ± standard deviation (STDV). Statistical analysis was performed with unpaired-two-tailed t test (P < 0.05). MFS Marfan syndrome, HVs healthy volunteers; AUC area under the receiver operating characteristic curve