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Table 1 Significantly expressed miRNAs in the blood of patients with MFS (n = 7) compared HVs controls (n = 7) as determined by microarray (unpaired two-tailed t test. P < 0.05, FDR adjusted)

From: Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome

miRNA

Median log2 MFS

Median log2 HVS

Fold change

Log2 fold change

Regulation

P value

Adjusted P value

AUC

hsa-miR-4271

− 3.32

4.40

0.0047

− 7.72

Down

0.0037

0.0689

0.95

hsa-miR-3616-3p

− 3.32

4.15

0.0056

− 7.47

Down

0.0003

0.0149

0.96

hsa-miR-1228

− 3.32

3.80

0.0072

− 7.12

Down

0.0004

0.0149

0.98

hsa-miR-1238

− 3.32

3.17

0.0111

− 6.49

Down

0.0169

0.1552

0.84

hsa-miR-191

− 3.32

3.03

0.0123

− 6.35

Down

0.0450

0.2177

0.80

hsa-miR-1234

0.94

4.02

0.12

− 3.09

Down

0.0004

0.0149

0.98

hsa-miR-4313

0.69

3.39

0.15

− 2.70

Down

0.0468

0.2177

0.78

hsa-miR-139-3p

0.65

3.15

0.18

− 2.50

Down

0.0001

0.0149

1.00

hsa-miR-874

2.83

4.76

0.26

− 1.92

Down

0.0042

0.0731

0.92

hsa-miR-564

4.70

5.90

0.43

− 1.20

Down

0.0003

0.0149

1.00

hsa-miR-940

3.06

4.21

0.45

− 1.15

Down

0.0004

0.0149

1.00

hsa-miR-1207-5p

5.80

6.93

0.46

− 1.13

Down

0.0319

0.1878

0.83

hsa-miR-1280

1.64

2.73

0.47

− 1.10

Down

0.0048

0.0790

0.98

hsa-miR-181d

3.93

4.99

0.48

− 1.06

Down

0.0277

0.1845

0.80

hsa-miR-1275

3.77

4.80

0.49

− 1.03

Down

0.0014

0.0323

0.94

hsa-miR-3653

7.04

8.01

0.51

− 0.97

Down

0.0484

0.2177

0.85

hsa-miR-1268

5.18

6.07

0.54

− 0.88

Down

0.0239

0.1739

0.89

hsa-miR-320b

10.66

11.48

0.57

− 0.82

Down

0.0085

0.1242

0.92

hsa-miR-532-3p

8.69

9.46

0.59

− 0.77

Down

0.0130

0.1444

0.84

hsa-miR-642b

3.17

3.93

0.59

− 0.76

Down

0.0179

0.1552

0.87

hsa-miR-4323

2.73

3.44

0.61

− 0.70

Down

0.0218

0.1675

0.87

hsa-miR-93

5.67

6.31

0.64

− 0.64

Down

0.0297

0.1871

0.80

hsa-miR-3162

6.83

7.46

0.65

− 0.63

Down

0.0068

0.1050

0.89

hsa-miR-3679-5p

4.53

5.13

0.66

− 0.59

Down

0.0278

0.1845

0.87

hsa-miR-423-5p

9.11

9.62

0.70

− 0.51

Down

0.0124

0.1433

0.86

hsa-miR-1225-5p

6.16

6.67

0.70

− 0.51

Down

0.0287

0.1852

0.84

hsa-miR-3651

4.99

5.44

0.73

− 0.45

Down

0.0478

0.2177

0.81

hsa-miR-638

5.98

6.41

0.74

− 0.43

Down

0.0193

0.1575

0.86

hsa-miR-766

4.84

5.25

0.76

− 0.40

Down

0.0238

0.1739

0.91

hsa-miR-191

5.10

5.49

0.76

− 0.39

Down

0.0350

0.1978

0.83

hsa-miR-762

4.55

4.73

0.88

− 0.18

Down

0.0403

0.2106

0.78

hsa-miR-221

2.77

− 3.32

68.19

6.09

Up

0.0499

0.2177

0.18

hsa-miR-1288

2.53

− 3.32

57.95

5.86

Up

0.0344

0.1978

0.21

hsa-miR-3125

2.35

− 3.32

50.81

5.67

Up

0.0481

0.2177

0.21

hsa-miR-500b

2.27

− 3.32

48.35

5.60

Up

0.0142

0.1462

0.14

hsa-miR-200c

2.13

− 3.32

43.66

5.45

Up

0.0142

0.1462

0.14

hsa-miR-3200-3p

2.07

− 3.32

41.98

5.39

Up

0.0280

0.1845

0.17

hsa-miR-3667-5p

1.81

− 3.32

35.05

5.13

Up

0.0380

0.2067

0.14

hsa-miR-627

1.74

− 3.32

33.47

5.06

Up

0.0311

0.1878

0.14

hsa-miR-664

1.33

− 3.32

25.09

4.65

Up

0.0395

0.2106

0.20

hsa-miR-223

13.58

11.98

3.04

1.60

Up

0.0496

0.2177

0.15

hsa-miR-660

4.28

2.92

2.57

1.36

Up

0.0192

0.1575

0.08

hsa-miR-29c

4.59

3.33

2.41

1.27

Up

0.0177

0.1552

0.00

hsa-miR-7

4.62

3.56

2.09

1.06

Up

0.0357

0.1978

0.12

hsa-miR-29a

6.93

5.98

1.93

0.95

Up

0.0117

0.1407

0.04

hsa-miR-500a

5.70

4.80

1.87

0.90

Up

0.0008

0.0202

0.04

hsa-miR-23a

9.46

8.57

1.85

0.89

Up

0.0103

0.1364

0.06

hsa-miR-151-5p

9.11

8.33

1.73

0.79

Up

0.0175

0.1552

0.09

hsa-miR-324-5p

6.20

5.41

1.72

0.79

Up

0.0005

0.0149

0.05

hsa-miR-4306

12.57

11.84

1.66

0.73

Up

0.0161

0.1552

0.08

hsa-miR-186

6.78

6.10

1.60

0.68

Up

0.0261

0.1845

0.12

hsa-miR-502-3p

5.53

4.87

1.58

0.66

Up

0.0005

0.0149

0.00

hsa-miR-23b

6.34

5.70

1.56

0.64

Up

0.0468

0.2177

0.18

hsa-miR-629

4.76

4.12

1.56

0.64

Up

0.0466

0.2177

0.20

hsa-miR-362-5p

6.34

5.74

1.52

0.60

Up

0.0005

0.0149

0.02

hsa-miR-652

9.07

8.47

1.51

0.60

Up

0.0116

0.1407

0.16

hsa-miR-24

7.95

7.38

1.48

0.57

Up

0.0018

0.0392

0.01

hsa-miR-501-3p

4.31

3.74

1.48

0.56

Up

0.0099

0.1364

0.04

hsa-miR-30e

5.97

5.49

1.39

0.48

Up

0.0027

0.0542

0.08

hsa-miR-331-3p

10.09

9.62

1.38

0.46

Up

0.0205

0.1621

0.16

hsa-miR-451

16.51

16.05

1.38

0.46

Up

0.0004

0.0149

0.06

hsa-miR-532-5p

5.94

5.53

1.33

0.41

Up

0.0318

0.1878

0.13

hsa-miR-103

10.66

10.25

1.33

0.41

Up

0.0478

0.2177

0.18

  1. Each value represents the median of 7 MFS patients and 7 HV controls and ± standard deviation (STDV). Statistical analysis was performed with unpaired-two-tailed t test (P < 0.05). MFS Marfan syndrome, HVs healthy volunteers; AUC area under the receiver operating characteristic curve