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Table 1 Significantly expressed miRNAs in the blood of patients with MFS (n = 7) compared HVs controls (n = 7) as determined by microarray (unpaired two-tailed t test. P < 0.05, FDR adjusted)

From: Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome

miRNA Median log2 MFS Median log2 HVS Fold change Log2 fold change Regulation P value Adjusted P value AUC
hsa-miR-4271 − 3.32 4.40 0.0047 − 7.72 Down 0.0037 0.0689 0.95
hsa-miR-3616-3p − 3.32 4.15 0.0056 − 7.47 Down 0.0003 0.0149 0.96
hsa-miR-1228 − 3.32 3.80 0.0072 − 7.12 Down 0.0004 0.0149 0.98
hsa-miR-1238 − 3.32 3.17 0.0111 − 6.49 Down 0.0169 0.1552 0.84
hsa-miR-191 − 3.32 3.03 0.0123 − 6.35 Down 0.0450 0.2177 0.80
hsa-miR-1234 0.94 4.02 0.12 − 3.09 Down 0.0004 0.0149 0.98
hsa-miR-4313 0.69 3.39 0.15 − 2.70 Down 0.0468 0.2177 0.78
hsa-miR-139-3p 0.65 3.15 0.18 − 2.50 Down 0.0001 0.0149 1.00
hsa-miR-874 2.83 4.76 0.26 − 1.92 Down 0.0042 0.0731 0.92
hsa-miR-564 4.70 5.90 0.43 − 1.20 Down 0.0003 0.0149 1.00
hsa-miR-940 3.06 4.21 0.45 − 1.15 Down 0.0004 0.0149 1.00
hsa-miR-1207-5p 5.80 6.93 0.46 − 1.13 Down 0.0319 0.1878 0.83
hsa-miR-1280 1.64 2.73 0.47 − 1.10 Down 0.0048 0.0790 0.98
hsa-miR-181d 3.93 4.99 0.48 − 1.06 Down 0.0277 0.1845 0.80
hsa-miR-1275 3.77 4.80 0.49 − 1.03 Down 0.0014 0.0323 0.94
hsa-miR-3653 7.04 8.01 0.51 − 0.97 Down 0.0484 0.2177 0.85
hsa-miR-1268 5.18 6.07 0.54 − 0.88 Down 0.0239 0.1739 0.89
hsa-miR-320b 10.66 11.48 0.57 − 0.82 Down 0.0085 0.1242 0.92
hsa-miR-532-3p 8.69 9.46 0.59 − 0.77 Down 0.0130 0.1444 0.84
hsa-miR-642b 3.17 3.93 0.59 − 0.76 Down 0.0179 0.1552 0.87
hsa-miR-4323 2.73 3.44 0.61 − 0.70 Down 0.0218 0.1675 0.87
hsa-miR-93 5.67 6.31 0.64 − 0.64 Down 0.0297 0.1871 0.80
hsa-miR-3162 6.83 7.46 0.65 − 0.63 Down 0.0068 0.1050 0.89
hsa-miR-3679-5p 4.53 5.13 0.66 − 0.59 Down 0.0278 0.1845 0.87
hsa-miR-423-5p 9.11 9.62 0.70 − 0.51 Down 0.0124 0.1433 0.86
hsa-miR-1225-5p 6.16 6.67 0.70 − 0.51 Down 0.0287 0.1852 0.84
hsa-miR-3651 4.99 5.44 0.73 − 0.45 Down 0.0478 0.2177 0.81
hsa-miR-638 5.98 6.41 0.74 − 0.43 Down 0.0193 0.1575 0.86
hsa-miR-766 4.84 5.25 0.76 − 0.40 Down 0.0238 0.1739 0.91
hsa-miR-191 5.10 5.49 0.76 − 0.39 Down 0.0350 0.1978 0.83
hsa-miR-762 4.55 4.73 0.88 − 0.18 Down 0.0403 0.2106 0.78
hsa-miR-221 2.77 − 3.32 68.19 6.09 Up 0.0499 0.2177 0.18
hsa-miR-1288 2.53 − 3.32 57.95 5.86 Up 0.0344 0.1978 0.21
hsa-miR-3125 2.35 − 3.32 50.81 5.67 Up 0.0481 0.2177 0.21
hsa-miR-500b 2.27 − 3.32 48.35 5.60 Up 0.0142 0.1462 0.14
hsa-miR-200c 2.13 − 3.32 43.66 5.45 Up 0.0142 0.1462 0.14
hsa-miR-3200-3p 2.07 − 3.32 41.98 5.39 Up 0.0280 0.1845 0.17
hsa-miR-3667-5p 1.81 − 3.32 35.05 5.13 Up 0.0380 0.2067 0.14
hsa-miR-627 1.74 − 3.32 33.47 5.06 Up 0.0311 0.1878 0.14
hsa-miR-664 1.33 − 3.32 25.09 4.65 Up 0.0395 0.2106 0.20
hsa-miR-223 13.58 11.98 3.04 1.60 Up 0.0496 0.2177 0.15
hsa-miR-660 4.28 2.92 2.57 1.36 Up 0.0192 0.1575 0.08
hsa-miR-29c 4.59 3.33 2.41 1.27 Up 0.0177 0.1552 0.00
hsa-miR-7 4.62 3.56 2.09 1.06 Up 0.0357 0.1978 0.12
hsa-miR-29a 6.93 5.98 1.93 0.95 Up 0.0117 0.1407 0.04
hsa-miR-500a 5.70 4.80 1.87 0.90 Up 0.0008 0.0202 0.04
hsa-miR-23a 9.46 8.57 1.85 0.89 Up 0.0103 0.1364 0.06
hsa-miR-151-5p 9.11 8.33 1.73 0.79 Up 0.0175 0.1552 0.09
hsa-miR-324-5p 6.20 5.41 1.72 0.79 Up 0.0005 0.0149 0.05
hsa-miR-4306 12.57 11.84 1.66 0.73 Up 0.0161 0.1552 0.08
hsa-miR-186 6.78 6.10 1.60 0.68 Up 0.0261 0.1845 0.12
hsa-miR-502-3p 5.53 4.87 1.58 0.66 Up 0.0005 0.0149 0.00
hsa-miR-23b 6.34 5.70 1.56 0.64 Up 0.0468 0.2177 0.18
hsa-miR-629 4.76 4.12 1.56 0.64 Up 0.0466 0.2177 0.20
hsa-miR-362-5p 6.34 5.74 1.52 0.60 Up 0.0005 0.0149 0.02
hsa-miR-652 9.07 8.47 1.51 0.60 Up 0.0116 0.1407 0.16
hsa-miR-24 7.95 7.38 1.48 0.57 Up 0.0018 0.0392 0.01
hsa-miR-501-3p 4.31 3.74 1.48 0.56 Up 0.0099 0.1364 0.04
hsa-miR-30e 5.97 5.49 1.39 0.48 Up 0.0027 0.0542 0.08
hsa-miR-331-3p 10.09 9.62 1.38 0.46 Up 0.0205 0.1621 0.16
hsa-miR-451 16.51 16.05 1.38 0.46 Up 0.0004 0.0149 0.06
hsa-miR-532-5p 5.94 5.53 1.33 0.41 Up 0.0318 0.1878 0.13
hsa-miR-103 10.66 10.25 1.33 0.41 Up 0.0478 0.2177 0.18
  1. Each value represents the median of 7 MFS patients and 7 HV controls and ± standard deviation (STDV). Statistical analysis was performed with unpaired-two-tailed t test (P < 0.05). MFS Marfan syndrome, HVs healthy volunteers; AUC area under the receiver operating characteristic curve