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Table 2 Medical therapies used prior to start of LDN and concomitantly with LDN

From: Low dose Naltrexone for induction of remission in inflammatory bowel disease patients

  UC, 19 CD, 28 Combined, 47
Prior and concomitant therapies
 Therapies prior to LDN, N (%)
  5-ASA 17 (89%) 14 (50%) 31 (66%)
  Steroids 19 (100%) 28 (100%) 47 (100%)
  Immunosuppressives 18 (95%) 27 (96%) 45 (96%)
  Anti-TNF 16 (84%) 25 (89%) 41 (87%)
  Other 5 (26%) 2 (7%) 8 (15%)
 Concomitant therapies at start of LDN, N (%)
  5-ASA 7 (37%) 3 (11%) 10 (21%)
  Steroids 6 (32%) 18 (64%) 24 (51%)
  Immunosuppressives 8 (42%) 9 (32%) 17 (36%)
  Anti-TNF 5 (26%) 3 (11%) 8 (17%)
  Other 1 (5%) 2 (7%) 3 (6%)
  None 4 (21%) 7 (25%) 11 (23%)
  1. Steroids refer to any form of corticosteroids. Immunosuppressives refer to thiopurines or methotrexate. Other refers to tacrolimus, cyclosporine, thioguanine or blinded trial drugs
  2. anti-TNF anti-tumor necrosis factor, CD Crohn’s disease, LDN low dose Naltrexone, UC ulcerative colitis