Fig. 5

High ER stress in mucosa from IBD patients is reduced by low dose Naltrexone treatment. a Example of GRP78, showing high ER stress marker expression in crypts as well as lamina propria. b GRP78 intensity was scored in lamina propria and crypts from biopsies taken from 13 patients before start of low dose Naltrexone and 5 patients 3 months into treatment. Lower levels of GRP78 expression were observed in lamina propria, although this did not reach statistical significance. c Paired biopsies were available from three patients. All three showed reduction of GRP78 expression in the lamina propria upon treatment with low dose Naltrexone. d Two paired samples are shown. Patient A was a non-responder, Patient B did show clinical response to low dose Naltrexone