TY - JOUR AU - Lie, Mitchell R. K. L. AU - van der Giessen, Janine AU - Fuhler, Gwenny M. AU - de Lima, Alison AU - Peppelenbosch, Maikel P. AU - van der Ent, Cokkie AU - van der Woude, C. Janneke PY - 2018 DA - 2018/03/09 TI - Low dose Naltrexone for induction of remission in inflammatory bowel disease patients JO - Journal of Translational Medicine SP - 55 VL - 16 IS - 1 AB - Around 30% of patients with inflammatory bowel disease (IBD) are refractory to current IBD drugs or relapse over time. Novel treatments are called for, and low dose Naltrexone (LDN) may provide a safe, easily accessible alternative treatment option for these patients. We investigated the potential of LDN to induce clinical response in therapy refractory IBD patients, and investigated its direct effects on epithelial barrier function. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-018-1427-5 DO - 10.1186/s12967-018-1427-5 ID - Lie2018 ER -