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Table 3 Rabbit ACLT study—cartilage µCT data

From: The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

  Medial Lateral Total
Thickness (µm) Volume (mm3) Thickness (µm) Volume (mm3) Thickness (µm) Volume (mm3)
Femur
 Sham-vehicle 276 ± 5* 23.2 ± 0.9* 223 ± 8* 18.2 ± 1.5* 250 ± 3** 41.4 ± 2.0*
 ACLT-vehicle 345 ± 15 31.1 ± 2.2 272 ± 15 23.9 ± 2.2 309 ± 14 55.0 ± 4.2
 ACLT-low dose 310 ± 18 27.5 ± 2.6 257 ± 13 23.1 ± 1.1 283 ± 15 50.6 ± 3.5
 ACLT-high dose 306 ± 12 27.2 ± 1.6 251 ± 12 23.0 ± 1.1 278 ± 11 50.2 ± 2.2
Tibia
 Sham-vehicle 558 ± 15 26.9 ± 1.0 349 ± 7 20.0 ± 0.6 444 ± 10 46.8 ± 1.4
 ACLT-vehicle 611 ± 17 28.8 ± 1.2 402 ± 12 23.9 ± 1.2 494 ± 12 52.8 ± 2.2
 ACLT-low dose 533 ± 26* 24.9 ± 1.5 349 ± 18 19.6 ± 1.3 432 ± 20* 44.5 ± 2.6
 ACLT-high dose 539 ± 25 25.3 ± 1.2 369 ± 24 21.6 ± 2.0 445 ± 22 46.9 ± 3.1
  1. p < 0.05; vs. ACLT-vehicle group
  2. ** P<0.01 vs. ACLT-vehicle group