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Table 3 Rabbit ACLT study—cartilage µCT data

From: The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

 

Medial

Lateral

Total

Thickness (µm)

Volume (mm3)

Thickness (µm)

Volume (mm3)

Thickness (µm)

Volume (mm3)

Femur

 Sham-vehicle

276 ± 5*

23.2 ± 0.9*

223 ± 8*

18.2 ± 1.5*

250 ± 3**

41.4 ± 2.0*

 ACLT-vehicle

345 ± 15

31.1 ± 2.2

272 ± 15

23.9 ± 2.2

309 ± 14

55.0 ± 4.2

 ACLT-low dose

310 ± 18

27.5 ± 2.6

257 ± 13

23.1 ± 1.1

283 ± 15

50.6 ± 3.5

 ACLT-high dose

306 ± 12

27.2 ± 1.6

251 ± 12

23.0 ± 1.1

278 ± 11

50.2 ± 2.2

Tibia

 Sham-vehicle

558 ± 15

26.9 ± 1.0

349 ± 7

20.0 ± 0.6

444 ± 10

46.8 ± 1.4

 ACLT-vehicle

611 ± 17

28.8 ± 1.2

402 ± 12

23.9 ± 1.2

494 ± 12

52.8 ± 2.2

 ACLT-low dose

533 ± 26*

24.9 ± 1.5

349 ± 18

19.6 ± 1.3

432 ± 20*

44.5 ± 2.6

 ACLT-high dose

539 ± 25

25.3 ± 1.2

369 ± 24

21.6 ± 2.0

445 ± 22

46.9 ± 3.1

  1. * p < 0.05; vs. ACLT-vehicle group
  2. ** P<0.01 vs. ACLT-vehicle group