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Table 1 Rabbit ACLT study—µCT data from subchondral bone plate

From: The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

  Medial Lateral Total
Thickness (µm) Volume (mm3) Thickness (µm) Volume (mm3) Thickness (µm) Volume (mm3)
Femur
 Sham-vehicle 368 ± 6 27.3 ± 1.0 325 ± 6* 23.6 ± 1.5 346 ± 6* 50.8 ± 2.5
 ACLT-vehicle 324 ± 25 25.0 ± 2.1 268 ± 14 20.5 ± 1.2 296 ± 16 45.5 ± 3.1
 ACLT-low dose 380 ± 13* 29.4 ± 0.8 316 ± 10 25.0 ± 0.6* 347 ± 10** 54.4 ± 0.8*
 ACLT-high dose 388 ± 9* 29.9 ± 1.0 321 ± 11* 25.7 ± 1.2* 353 ± 8** 55.6 ± 2.0*
Tibia
 Sham-vehicle 450 ± 10 20.9 ± 0.6 330 ± 10* 19.4 ± 0.7* 383 ± 19* 40.3 ± 1.1*
 ACLT-vehicle 424 ± 22 19.4 ± 1.2 243 ± 12 14.1 ± 0.9 324 ± 14 33.4 ± 1.7
 ACLT-low dose 452 ± 15 20.6 ± 0.8 326 ± 18* 18.5 ± 1.3* 383 ± 15* 39.1 ± 2.0*
 ACLT-high dose 462 ± 13 20.6 ± 0.5 353 ± 12* 20.7 ± 1.0* 401 ± 8** 41.2 ± 0.9*
  1. p < 0.05; ** p < 0.01 vs. ACLT-vehicle group