Skip to main content

Table 1 Rabbit ACLT study—µCT data from subchondral bone plate

From: The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

 

Medial

Lateral

Total

Thickness (µm)

Volume (mm3)

Thickness (µm)

Volume (mm3)

Thickness (µm)

Volume (mm3)

Femur

 Sham-vehicle

368 ± 6

27.3 ± 1.0

325 ± 6*

23.6 ± 1.5

346 ± 6*

50.8 ± 2.5

 ACLT-vehicle

324 ± 25

25.0 ± 2.1

268 ± 14

20.5 ± 1.2

296 ± 16

45.5 ± 3.1

 ACLT-low dose

380 ± 13*

29.4 ± 0.8

316 ± 10

25.0 ± 0.6*

347 ± 10**

54.4 ± 0.8*

 ACLT-high dose

388 ± 9*

29.9 ± 1.0

321 ± 11*

25.7 ± 1.2*

353 ± 8**

55.6 ± 2.0*

Tibia

 Sham-vehicle

450 ± 10

20.9 ± 0.6

330 ± 10*

19.4 ± 0.7*

383 ± 19*

40.3 ± 1.1*

 ACLT-vehicle

424 ± 22

19.4 ± 1.2

243 ± 12

14.1 ± 0.9

324 ± 14

33.4 ± 1.7

 ACLT-low dose

452 ± 15

20.6 ± 0.8

326 ± 18*

18.5 ± 1.3*

383 ± 15*

39.1 ± 2.0*

 ACLT-high dose

462 ± 13

20.6 ± 0.5

353 ± 12*

20.7 ± 1.0*

401 ± 8**

41.2 ± 0.9*

  1. * p < 0.05; ** p < 0.01 vs. ACLT-vehicle group