Fig. 2

Effect of MIV-711 on urinary concentrations of a the bone resorption biomarker HP-1 and b the cartilage degradation biomarker CTX-II. Mean ± SEM, n = 5–7 per time point. *p < 0.05, **p < 0.01, ***p < 0.001 vs. ACLT-vehicle group. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. respective baseline