Fig. 4
From: Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia
Apatinib down-regulates the phosphorylation of VEGFR2 and its downstream signaling pathway in ALL cells. Jurkat (a), Nalm6 (b) cells were treated with 0, 10, 20 and 40 μM Apatinib for 48 h, respectively. The protein level of VEGFR2, p-VEGFR2 and its downstream signaling pathways were examined by western blotting. β-actin and GAPDH was used as a loading control in this experiment