| Placebo (n = 4) | PRG 3.9M (n = 8) | PRG 6.7M (n = 8) | Placebo – PRG 3.9M | Placebo – PRG 6.7M |
---|---|---|---|---|---|
Lateral tibial cartilage volume, mm3 | − 95.4 (− 172.6, − 18.2) p = 0.019 | 11.1 (− 37.1, 59.3) p = 0.628 | − 78.0 (− 125.9, − 30.1) p = 0.004 | 106.5 (13.6, 199.4) p = 0.028 | 17.4 (− 74.6, 109.4) p = 0.690 |
Lateral tibial cartilage volume, % change | − 5.0 (− 8.8, − 1.3) p = 0.012 | 0.4 (− 2.0, 2.7) p = 0.730 | − 3.5 (− 5.8, − 1.2) p = 0.006 | 5.4 (0.9, 9.9) p = 0.022 | 1.5 (− 2.9, 6.0) p = 0.475 |
Medial tibial cartilage volume, mm3 | − 15.4 (− 166.8, − 136.0) p = 0.830 | − 30.3 (− 141.2, 80.5) p = 0.567 | − 73.8 (− 186.1, 38.6) p = 0.181 | − 14.9 (− 203.2, 173.4) p = 0.868 | − 58.3 (− 250.6, 133.9) p = 0.526 |
Medial tibial cartilage volume, % change | − 1.7 (− 8.8, 5.3) p = 0.607 | − 1.5 (− 6.7, 3.6) p = 0.532 | − 3.5 (− 8.7, 1.8) p = 0.178 | 0.2 (− 8.6, 9.0) p = 0.964 | − 1.7 (− 10.7, 7.2) p = 0.685 |
Lateral tibial bone area, mm2 | − 10.0 (− 70.9, 50.9) p = 0.730 | − 8.5 (− 54.4, 37.4) p = 0.698 | 25.6 (− 71.6, 20.4) p = 0.253 | 1.5 (− 74.7, 77.7) p = 0.967 | − 15.6 (− 92.1, 60.9) p = 0.669 |
Lateral tibial bone area, % change | − 0.2 (− 4.0, 3.6) p = 0.906 | − 0.2 (− 3.1, 2.7) p = 0.888 | − 2.0 (− 4.9, 0.9) p = 0.158 | 0.0 (− 4.8, 4.8) p = 0.993 | − 1.8 (− 6.6, 3.0) p = 0.436 |
Medial tibial bone area, mm2 | 30.4 (− 41.6, 102.4) p = 0.381 | 50.3 (1.1, 99.6) p = 0.046 | − 17.0 (− 68.1, 34.1) p = 0.487 | 20.0 (− 68.6, 108.5) p = 0.636 | − 47.4 (− 140.4, 45.6) p = 0.293 |
Medial tibial bone area, % change | 1.4 (− 1.6, 4.3) p = 0.336 | 2.0 (− 0.0, 4.0) p = 0.051 | − 1.0 (− 3.1, 1.1) p = 0.326 | 0.6 (− 3.0, 4.3) p = 0.712 | − 2.4 (− 6.2, 1.4) p = 0.205 |