Safety, tolerability and efficacy of intra-articular Progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study

Table 4 Summary of abnormal clinically significant haematology and clinical chemistry results

Group	Parameter	Visit	Value	Laboratory reference range (low, high)	Status
Placebo	Neutrophils	Month 12	1.6 10⁹/L	(2, 7.5)	L
	WBC	Month 12	3.6 10⁹/L	(4, 11)	L
PRG 6.7M	ALT	Month 12	69 U/L	(5, 40)	H
	AST	Month 12	96 U/L	(10, 40)	H
PRG 6.7M	Potassium	Month 6	5.6 mmol/L	(3.5, 5.5)	H

H, higher than laboratory reference range; L, lower than laboratory reference range; ALT, alanine aminotransferase; AST, aspartate aminotransferase; WBC, white blood cells

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