Table 4 Multivariable Cox regression analysis of disease specific survival
Variable | Hazards ratio (95% CI) | P value |
|---|---|---|
Colon and rectal samples (N = 214) | ||
Age (< 60 vs. ≥ 60) | 1.476 (1.085–2.008) | 0.013 |
Stage (I/II vs. III) | 1.007 (0.657–1.544) | 0.974 |
Stage (I/II vs. IV) | 1.862 (1.295–2.677) | 0.001 |
Neoadjuvant treatment (no vs. yes) | 1.212 (0.879–1.673) | 0.241 |
SEPT9 methylation (non-Hyper. vs. hypermethylated) | 0.673 (0.469–0.965) | 0.031 |
Colon samples (N = 110) | ||
Age (< 60 vs. >=60) | 1.730 (1.079–2.773) | 0.023 |
Stage (I/II vs. III) | 0.966 (0.486–1.922) | 0.922 |
Stage (I/II vs. IV) | 1.454 (0.859–2.463) | 0.164 |
Neoadjuvant treatment (no vs. yes) | 1.237 (0.677–2.259) | 0.490 |
Tumor location (distal vs. proximal) | 1.879 (1.174–3.007) | 0.009 |
SEPT9 methylation (non-Hyper. vs. hypermethylated) | 0.472 (0.276–0.806) | 0.006 |