Table 3 SEPT9 promoter methylation and 3-gene panel sensitivity values for CRC detection according with location, stage and CIMP and MSI status
Diagnosis group | SEPT9 | SEPT9, MGMT, RASSF1A |
|---|---|---|
Location | ||
Colon | 84.0 (79/94) | 95.7 (90/94) |
Proximal | 86.7 (26/30) | 93.3 (28/30) |
Distal | 82.8 (53/64) | 96.9 (62/64) |
Rectum | 88.2 (45/51) | 98.0 (50/51) |
Stage | ||
Stage I and II | 91.4 (32/35) | 100 (35/35) |
Stage III | 80.0 (28/35) | 94.2 (33/35) |
Stage IV | 84.9 (62/73) | 95.9 (70/73) |
CIMP | ||
CIMP-negative | 85.5 (112/131) | 96.9 (127/131) |
CIMP-positive | 90.9 (10/11) | 100 (11/11) |
MSI | ||
MSI-L/MSS | 85.4 (117/137) | 97.1 (133/137) |
MSI-H | 87.5 (7/8) | 87.5 (7/8) |