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Table 3 SEPT9 promoter methylation and 3-gene panel sensitivity values for CRC detection according with location, stage and CIMP and MSI status

From: A novel DNA methylation panel accurately detects colorectal cancer independently of molecular pathway

Diagnosis group SEPT9 SEPT9, MGMT, RASSF1A
Location
 Colon 84.0 (79/94) 95.7 (90/94)
 Proximal 86.7 (26/30) 93.3 (28/30)
 Distal 82.8 (53/64) 96.9 (62/64)
 Rectum 88.2 (45/51) 98.0 (50/51)
Stage
 Stage I and II 91.4 (32/35) 100 (35/35)
 Stage III 80.0 (28/35) 94.2 (33/35)
 Stage IV 84.9 (62/73) 95.9 (70/73)
CIMP
 CIMP-negative 85.5 (112/131) 96.9 (127/131)
 CIMP-positive 90.9 (10/11) 100 (11/11)
MSI
 MSI-L/MSS 85.4 (117/137) 97.1 (133/137)
 MSI-H 87.5 (7/8) 87.5 (7/8)
  1. CIMP CpG island methylator phenotype, MSI microsatellite instability, MSI-H MSI high, MSI-L MSI low, MSS microsatellite stable, n number of positive cases, N total of cases in each group
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