Association of chronic fatigue syndrome with premature telomere attrition

Table 4 Adjusted T/S ratio means, calculated TRF length difference and accelerated aging in fatigued groups with respect to NF in the study sample (n = 639)

CFS status	Unadjusted T/S ratio means (SEM) F = 5.13**	Adjusted T/S ratio means (SEM)^a F = 2.61**	Mean TRF length (bp) difference with respect to NF^b,c	Equivalent additional years in aging with respect to NF^c
CFS	0.90 (0.03)	0.90 (0.05)	673 (635)	10.7–21.7 (10.1–20.5)
CFS-X	0.97 (0.04)	0.99 (0.05)	360 (254)	5.7–11.6 (4.0–8.2)
ISF	0.94 (0.02)	0.95 (0.03)	500 (424)	7.9–16.1 (6.6–13.7)
NF	1.06 (0.04)	1.05 (0.04)	Reference	Reference

** p < 0.01
^aAdjusted for sample characteristics including age, sex, education, BMI, WHR and PEM
^bTRF length (bp) refers to terminal restriction fragment length in base pairs
^cValues outside and inside the parenthesis represent those based on unadjusted and adjusted mean T/S ratios, respectively

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