Association of chronic fatigue syndrome with premature telomere attrition

Table 3 Association of demographic and biological measures with telomere length

Variable	Telomere length (T/S ratio)^a
Variable	β (standard error)	p-value
Age	− 0.0051 (0.0015)	0.0009
BMI	− 0.0067 (0.0027)	0.0145
WHR	− 0.4357 (0.1784)	0.0149
Sex (female vs. male)	0.0333 (0.0339)	0.3260
Race		0.6062
White	Reference
Black	0.0326 (0.0358)	0.3633
Other	− 0.0381 (0.1089)	0.7264
Residential area		0.9128
Urban	Reference
Rural	− 0.0016 (0.0329)	0.9607
Metro	0.0159 (0.0442)	0.7199
Education		0.0288
Less than High School	0.1176 (0.0707)	0.0970
≥ HS ≤ 2 year College	0.1016 (0.0367)	0.0059
4-year College	0.0365 (0.0470)	0.4381
Graduate	Reference
Income		0.1298
≤ $20,000	− 0.0925 (0.0460)	0.0445
$20,001–$40,000	− 0.0226 (0.0411)	0.5821
≥ $40,001	Reference
Post-exertional malaise
Yes vs. no	− 0.0521 (0.0321)	0.0153
Triglycerides (mg/dL)	− 0.0002 (0.0002)	0.3426
HDL (mg/dL)	0.0004 (0.0009)	0.6233
Heart rate (bpm)	− 0.0006 (0.0017)	0.7009
Blood pressure: systolic (mmHg)	− 0.0011 (0.0010)	0.2367
Blood pressure: diastolic (mmHg)	0.0005 (0.0015)	0.7211
Fasting glucose (mg/dL)	− 0.0017 (0.0009)	0.0625
Insulin (µIU/mL)	− 0.0009 (0.0022)	0.6856
CRP (mg/dL)	− 0.0054 (0.0030)	0.0789
Albumin (g/dL)	0.0487 (0.0621)	0.4332

^aT/S ratio of a subject is the ratio of telomere PCR signal (T) to the single copy gene PCR signal (S). The T/S ratio is proportional to the average telomere length per cell and is expressed relative to the T/S ratio of a reference DNA

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