Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients

Table 2 Summary of experimental data obtained from the same study groups

Measurements	COPD versus health Summary of results
Plasma metabolomics [19]	The two groups showed differences in metabolomic profiles at rest (P < 0.05). Levels of valine, alanine and isoleucine were associated with FFMI (P < 0.01 each)
Plasma metabolomics training diff [19]	In Healthy, training generated marked changes in amino acids, creatine, succinate, pyruvate, glucose and lactate (P < 0.05 each). But, COPD patients only showed lactate decrease (P < 0.05)
Inflammatory cytokines [20]	COPD patients showed high levels of circulating cytokines (P < 0.05), not seen in healthy
Inflammatory cytokines training diff [20]	No training-induced changes were observed in circulating cytokines levels
Redox status [20]	COPD patients showed blood and muscle oxidative stress at baseline. Muscle and blood protein carbonylation levels were correlated (P < 0.05)
Redox status training diff [20]	In COPD patients, protein nitration levels decreased after training

Summary description of the results of previous experimental measurements on plasma metabolomics [19], as well as on both muscle and blood inflammatory cytokines and redox status [20], carried out at rest before training and after endurance training. The term training diff refers to training-induced adaptive changes. For comprehensive list of measured variables see Additional file 2: Tables S2, S7 for the differentials

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