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Table 1 Characteristics of the study groups

From: Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients

  Healthy COPD
Sex (M/F) 10/2 15/0
Age, years 65 ± 9 69 ± 7
FFMI, kg/m2 21 ± 2 19 ± 3
FEV1, L (mean % pred) 3.46 ± 0.69 (107) 1.34 ± 0.37 (46)*
FEV1/FVC 0.75 ± 0.04 0.43 ± 0.08*
VO2 peak, L/min (mean VO2 peak/kg) 1.70 ± 0.5 (22) 0.91 ± 0.3 (14)*
[La]a peak, mEq/L 10.60 ± 2.7 6.8 ± 2.3*
VO2 peak training diff (post–pre), L/min 0.25 ± 0.11 0.14 ± 0.18
[La]a training diff (post–pre), mEq/L − 4.60 ± 0.6 − 1.5 ± 2
  1. Results are expressed as mean ± SD
  2. In the post-training study, lactate measurements during constant-work rate exercise were done at the same workload and duration than the pre-training exercise protocol
  3. FFMI fat free mass index, FEV 1 forced expiratory volume in the first second, FEV1/FVC FEV1 to forced vital capacity ratio, VO 2 peak peak oxygen uptake difference post minus pre-training, [La]a arterial lactate concentration difference
  4. Unpaired t test was used to compare controls and COPD, * P < 0.05. Paired t test was used to compare post-training and baseline time points in both healthy controls and COPD patients, P < 0.05. Low FFMI was defined as < 17.05 kg/m2 for men [21]. It is of note that three COPD patients were discarded from the analysis because they did not pass the Agilent analysis