| |
Healthy
|
COPD
|
|---|
|
Sex (M/F)
|
10/2
|
15/0
|
|
Age, years
|
65 ± 9
|
69 ± 7
|
|
FFMI, kg/m2
|
21 ± 2
|
19 ± 3
|
|
FEV1, L (mean % pred)
|
3.46 ± 0.69 (107)
|
1.34 ± 0.37 (46)*
|
|
FEV1/FVC
|
0.75 ± 0.04
|
0.43 ± 0.08*
|
|
VO2 peak, L/min (mean VO2 peak/kg)
|
1.70 ± 0.5 (22)
|
0.91 ± 0.3 (14)*
|
|
[La]a peak, mEq/L
|
10.60 ± 2.7
|
6.8 ± 2.3*
|
|
VO2 peak training diff (post–pre), L/min
|
0.25 ± 0.11†
|
0.14 ± 0.18†
|
|
[La]a training diff (post–pre), mEq/L
|
− 4.60 ± 0.6†
|
− 1.5 ± 2†
|
- Results are expressed as mean ± SD
- In the post-training study, lactate measurements during constant-work rate exercise were done at the same workload and duration than the pre-training exercise protocol
- FFMI fat free mass index, FEV
1
forced expiratory volume in the first second, FEV1/FVC FEV1 to forced vital capacity ratio, VO
2
peak peak oxygen uptake difference post minus pre-training, [La]a arterial lactate concentration difference
- Unpaired t test was used to compare controls and COPD, * P < 0.05. Paired t test was used to compare post-training and baseline time points in both healthy controls and COPD patients, †P < 0.05. Low FFMI was defined as < 17.05 kg/m2 for men [21]. It is of note that three COPD patients were discarded from the analysis because they did not pass the Agilent analysis
