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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation

Fig. 1

Approaches for modification of mesenchymal stem cell therapy for application in patient-based trials. The primary approach is to identify the optimal cell source and conditions to be maintained for their expansion, followed by the functional characterisation of these cells through in vitro and animal studies. Secondly, determination of the dosage, route of administration and infusion time points through animal studies and pilot trials is crucial. Further, before applying MSCs for patient care, determination of patient profile is important, as this will allow us to establish whether these cells require any modifications to enhance their therapeutic efficacy or not. Finally, autologous or allogeneic MSCs isolated from an optimal source and expanded in favourable culture conditions can either be applied directly to the patients or can be modified as per the patient’s profile and then applied to the patients after assessment of their genetic stability

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