Table 7 Typical examples of nVGDS for neuronal repair and regeneration
From: Non-viral gene delivery systems for tissue repair and regeneration
Chemical vector | Scaffold/matrices | Wound type | Animal/cell | DNA/RNA | References |
|---|---|---|---|---|---|
Melittin-modified polymers | None | None | HeLa and neuron-like PC-12 cells | pDNA-GFP | [85] |
Lipoplexes (Transfast) | ECM-coated PLG three-dimensional bridges | Spinal cord hemisection injury | Rat | pDNA-firefly luciferase and pDNA-b-galactosidase | [164] |
Lipoplexes (Transfast) | Poly(lactide-co-glycolide) (PLG) bridges | Spinal cord hemisection injury | Rat/primary dorsal root ganglion (DRG) neurons and HEK293T cells | pDNA-GF pDNA-NGF | [165] |