Table 5 Typical examples of nVGDS for tendon repair and regeneration
From: Non-viral gene delivery systems for tissue repair and regeneration
Chemical vector | Scaffold/matrices | Wound type | Animal/cell | DNA/RNA | References |
|---|---|---|---|---|---|
Amino- and carboxyl-modified MCM-41 mesoporous silica nanoparticles (MSN) | None | Achilles tendon injury | Rat/primary tenocytes | pDNA-PDGF-B | [155] |
Histidylated vectors (Lip100 and PTG1) | None | Achilles tendon injury | Wistar rats/tenocytes | pDNA-CEP4-FBM | [157] |
Polylactic-co-glycolic acid nanospheres | None | Injured flexor tendon | Chicken | miRNAplasmid suppressing TGF-b1 | [158] |