Table 4 Typical examples of nVGDS for cartilage repair and regeneration
From: Non-viral gene delivery systems for tissue repair and regeneration
Chemical vector | Scaffold/matrices | Wound type | Animal/cell | DNA/RNA | References |
|---|---|---|---|---|---|
Hyaluronic acid/chitosan | Chitosan scaffolds | None | Chondrocytes | pDNA-TGF-β1 | [147] |
PLGA nanoparticles | None | Subcutaneous implantation model | Female BALB/c mice/hMSCs | pDNA-SOX9 | [148] |
PEI | PLGA scaffolds | None | Rat/BMSCs | pDNA-IGF-1 | [149] |
Alginate polysaccharide microcapsules | None | None | hBMSCs and articular chondrocytes | pDNA-SOX9 | [150] |
Turbofect | Gelatin-oxidized dextran scaffolds | Auricular cartilage defect | New Zealand (NZ) white rabbits | pDNA-BMP7 | [151] |
FuGENE 6 | PGA scaffold | Osteochondral defects in spatellar groove | Male Chinchilla bastard rabbits/chondrocytes | pCMVhIGF-I | [152] |
GenePORTER™ 2 (GP2) | Collagen scaffolds | None | MSCs | Plasmid endostatin | [153] |