Skip to main content

Table 1 The regulation of myeloid-derived suppressor cells (MDSCs) by immunosuppressive drugs

From: Myeloid-derived suppressor cells in transplantation: the dawn of cell therapy

Immunosuppressive drug

Year

Disease model

Induction of MDSCs

Mechanism

Ref.

Cyclosporine A

2014

Skin transplantation

Yes

Calcineurin-NFAT-IDO

[85]

Rapamycin

2015

Cardiac transplantation

Yes

iNOS/Arg-1

[51]

Rapamycin

2017

AKI

Yes

iNOS/Arg-1

[86]

Rapamycin

2015

Skin transplantation

No

iNOS/Arg-1

[87]

Dexamethasone

2014

Skin transplantation

Yes

GC-GR-NO

[91]

Dexamethasone

2017

Immunological hepatic injury

Yes

GC-GR-H1α

[92]

  1. AKI acute kidney injury, IDO indoleamine 2, 3-dioxygenase, Arg-1 arginase-1