From: Myeloid-derived suppressor cells in transplantation: the dawn of cell therapy
Immunosuppressive drug | Year | Disease model | Induction of MDSCs | Mechanism | Ref. |
---|---|---|---|---|---|
Cyclosporine A | 2014 | Skin transplantation | Yes | Calcineurin-NFAT-IDO | [85] |
Rapamycin | 2015 | Cardiac transplantation | Yes | iNOS/Arg-1 | [51] |
Rapamycin | 2017 | AKI | Yes | iNOS/Arg-1 | [86] |
Rapamycin | 2015 | Skin transplantation | No | iNOS/Arg-1 | [87] |
Dexamethasone | 2014 | Skin transplantation | Yes | GC-GR-NO | [91] |
Dexamethasone | 2017 | Immunological hepatic injury | Yes | GC-GR-H1α | [92] |