Table 1 Baseline characteristics of 123 patients with hypopharyngeal squamous cell carcinoma
Characteristics | N (%) | PNI | P valuea | |
|---|---|---|---|---|
> 52.0 | ≤ 52.0 | |||
Age (years) | ||||
 ≤ 60 | 87 | 46 | 41 |  |
 > 60 | 36 | 13 | 23 | 0.090 |
Sex | ||||
 Male | 121 (98.4) | 59 | 62 |  |
 Female | 2 (1.6) | 0 | 2 | 0.497 |
Smoking history | ||||
 No | 28 (22.8) | 13 | 15 |  |
 Yes | 95 (77.2) | 46 | 49 | 0.853 |
Alcohol history | ||||
 No | 41 (33.3) | 19 | 22 |  |
 Yes | 82 (66.7) | 40 | 42 | 0.799 |
Pharyngolaryngectomy | ||||
 Total | 51 (41.5) | 28 | 23 |  |
 Partial | 72 (58.5) | 32 | 41 | 0.195 |
Neck nodal dissection | ||||
 Bilateral | 42 (34.1) | 23 | 19 |  |
 Unilateral | 81 (65.9) | 36 | 45 | 0.277 |
Tumor differentiation | ||||
 Well/moderate | 83 (67.5) | 38 | 45 |  |
 Poor | 40 (32.5) | 21 | 19 | 0.485 |
Primary tumor site | ||||
 Pyriform sinus | 108 (87.8) | 53 | 55 |  |
 Posterior wall/postcricoid | 15 (12.2) | 6 | 9 | 0.510 |
pT classificationb | ||||
 T1–T2 | 87 (70.7) | 43 | 44 |  |
 T3–T4 | 36 (29.3) | 16 | 20 | 0.615 |
pN classificationb | ||||
 N0 | 20 (16.3) | 11 | 9 |  |
 N1–3 | 103 (83.7) | 48 | 55 | 0.491 |
pTNM stagingb | ||||
 I–II | 18 (14.6) | 10 | 8 |  |
 III–IV | 105 (85.4) | 49 | 56 | 0.486 |
No. of metastatic LN | ||||
 ≤ 3 | 98 (79.7) | 46 | 52 |  |
 > 3 | 25 (20.3) | 13 | 12 | 0.651 |
LND | ||||
 ≤ 0.06 | 66 (53.7) | 31 | 35 |  |
 > 0.06 | 57 (46.3) | 28 | 29 | 0.812 |
ECS of LN | ||||
 Negative | 104 (84.6) | 50 | 54 |  |
 Positive | 19 (15.4) | 9 | 10 | 0.955 |
Surgical margin | ||||
 Negative | 115 (93.5) | 55 | 60 |  |
 Positive | 8 (6.5) | 4 | 4 | 1.000b |
Perineural invasion | ||||
 Negative | 108 (87.8) | 52 | 56 |  |
 Positive | 15 (12.2) | 7 | 8 | 0.914 |
Lymphovascular invasion | ||||
 Negative | 99 (80.5) | 46 | 53 |  |
 Positive | 24 (19.5) | 13 | 11 | 0.498 |
Adjuvant treatment | ||||
 No | 8 (6.5) | 4 | 4 |  |
 RT alone | 59 (48.0) | 30 | 29 |  |
 CRT | 56 (45.5) | 29 | 31 | 0.796 |
Disease progression | ||||
 Absence | 56 (45.5) | 38 | 18 |  |
 Presence | 67 (54.5) | 21 | 46 | 0.000 |