Fig. 2

Clinical Data for Discovery and Testing Cohorts. Discovery cohort: (a, b). a Breakdown of disease severity by CDAI scores for the discovery cohort at Baseline and 6 months. b Change in CDAI scores between responders (R) and non-responders (NR) at Baseline and 6 months following MTX therapy. Testing cohort: (c, d). c Breakdown of disease severity by CDAI scores for the testing cohort at Baseline and 6 months. d Change in CDAI scores between responders (R) and non-responders (NR) at Baseline and 6 months following MTX therapy. Significant reductions in CDAI scores were seen between R and NR at Baseline compared to R at 6 months as well as between NR and R at 6 months (****p<0.01). For CDAI scores see Additional file 1: Tables S2, S3