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Table 4 Uni- and multivariate Cox regression models for PFS (N = 86)

From: Expression of the Hippo transducer TAZ in association with WNT pathway mutations impacts survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy

  Univariate Cox regression model Multivariate Cox regression modela Multivariate Cox regression modelb
HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value
γ-H2AXpos/pATMpos
 Positive vs other 2.14 (1.30–3.53) 0.003 2.09 (1.27–3.45) 0.004 1.87 (1.04–3.39) 0.038
TAZpos/WNTmut
 Positive vs other 2.27 (1.27–4.05) 0.006 2.21 (1.23–3.97) 0.008 2.73 (1.41–5.29) 0.003
ECOG-PS
 1–2 vs 0 1.23 (0.77–1.97) 0.391    1.20 (0.73–1.95) 0.471
Stage
 Met vs loc adv 1.12 (0.69–1.80) 0.647    0.89 (0.46–1.73) 0.737
Localization
 Stomach vs EOJ 0.67 (0.27–1.69) 0.398    1.54 (0.53–4.42) 0.424
Number of metastatic sites
 2–3 vs 1 1.57 (0.93–2.65) 0.089    1.33 (0.70–2.50) 0.379
Peritoneal metastasis
 Yes vs No 0.67 (0.42–1.07) 0.097    0.72 (0.41–1.27) 0.261
Taxanes
 Yes vs No 0.93 (0.58–1.51) 0.784    0.79 (0.45–1.40) 0.429
  1. aAdjusted for the variables significant at the univariate analysis
  2. bAdjusted for all the variables tested at univariate analysis