|
Univariate Cox regression model
|
Multivariate Cox regression modela
|
Multivariate Cox regression modelb
|
---|
HR (95% CI)
|
p-value
|
HR (95% CI)
|
p-value
|
HR (95% CI)
|
p-value
|
---|
γ-H2AXpos/pATMpos
|
Positive vs other
|
2.14 (1.30–3.53)
|
0.003
|
2.09 (1.27–3.45)
|
0.004
|
1.87 (1.04–3.39)
|
0.038
|
TAZpos/WNTmut
|
Positive vs other
|
2.27 (1.27–4.05)
|
0.006
|
2.21 (1.23–3.97)
|
0.008
|
2.73 (1.41–5.29)
|
0.003
|
ECOG-PS
|
1–2 vs 0
|
1.23 (0.77–1.97)
|
0.391
| | |
1.20 (0.73–1.95)
|
0.471
|
Stage
|
Met vs loc adv
|
1.12 (0.69–1.80)
|
0.647
| | |
0.89 (0.46–1.73)
|
0.737
|
Localization
|
Stomach vs EOJ
|
0.67 (0.27–1.69)
|
0.398
| | |
1.54 (0.53–4.42)
|
0.424
|
Number of metastatic sites
|
2–3 vs 1
|
1.57 (0.93–2.65)
|
0.089
| | |
1.33 (0.70–2.50)
|
0.379
|
Peritoneal metastasis
|
Yes vs No
|
0.67 (0.42–1.07)
|
0.097
| | |
0.72 (0.41–1.27)
|
0.261
|
Taxanes
|
Yes vs No
|
0.93 (0.58–1.51)
|
0.784
| | |
0.79 (0.45–1.40)
|
0.429
|
- aAdjusted for the variables significant at the univariate analysis
- bAdjusted for all the variables tested at univariate analysis