Table 4 Uni- and multivariate Cox regression models for PFS (N = 86)
Univariate Cox regression model | Multivariate Cox regression modela | Multivariate Cox regression modelb | ||||
|---|---|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
γ-H2AXpos/pATMpos | ||||||
Positive vs other | 2.14 (1.30–3.53) | 0.003 | 2.09 (1.27–3.45) | 0.004 | 1.87 (1.04–3.39) | 0.038 |
TAZpos/WNTmut | ||||||
Positive vs other | 2.27 (1.27–4.05) | 0.006 | 2.21 (1.23–3.97) | 0.008 | 2.73 (1.41–5.29) | 0.003 |
ECOG-PS | ||||||
1–2 vs 0 | 1.23 (0.77–1.97) | 0.391 | 1.20 (0.73–1.95) | 0.471 | ||
Stage | ||||||
Met vs loc adv | 1.12 (0.69–1.80) | 0.647 | 0.89 (0.46–1.73) | 0.737 | ||
Localization | ||||||
Stomach vs EOJ | 0.67 (0.27–1.69) | 0.398 | 1.54 (0.53–4.42) | 0.424 | ||
Number of metastatic sites | ||||||
2–3 vs 1 | 1.57 (0.93–2.65) | 0.089 | 1.33 (0.70–2.50) | 0.379 | ||
Peritoneal metastasis | ||||||
Yes vs No | 0.67 (0.42–1.07) | 0.097 | 0.72 (0.41–1.27) | 0.261 | ||
Taxanes | ||||||
Yes vs No | 0.93 (0.58–1.51) | 0.784 | 0.79 (0.45–1.40) | 0.429 | ||