Peptide
|
Protien origin
|
Peptide sequence
|
MHC class I
|
Net MHC [32, 33]
|
Syfpeithi [34]
|
CD1d
|
Castano [55]
|
MHC class II
|
Net MHC II pan3.1 [35]
|
---|
1
|
RIM1
|
WEAKPSRIL
|
B*18
|
WB
|
+(17)
|
CD1d
|
−
|
DRB1*1101
|
NB
|
| | |
B*44
|
WB
| |
CD1d
|
−
|
DRB1*1301
|
NB
|
| |
(WEAKPSRI)
|
B*44
|
SB
|
+(21)
|
–
|
−
| | |
2
|
KIF4B
|
GIAARVKNWL
|
A*02
|
NB
|
+(22)
|
CD1d
|
+
|
DRB1*1101
|
WB
|
| | | | | | | |
DRB1*1301
|
WB
|
3
|
KIF4B
|
KEGIAARVKNW
|
B*44
|
WB
|
−(14)
|
CD1d
|
+
|
DRB1*1101
|
NB
|
| | | | | | | |
DRB1*1301
|
NB
|
| |
(EGIAARVKNW)
|
B*44
|
SB
|
−(14)
|
CD1d
|
+
| | |
4
|
RIM1
|
EAKPSRILM
|
A*02
|
NB
|
−(6)
|
CD1d
|
−
|
DRB1*1101
|
NB
|
| | | | | | | |
DRB1*1301
|
NB
|
- The binding scores of individual peptides for the patient’s HLA haplotypes were determined via NetMHC [32, 33], SYFPEITHI [34], CD1d-binding algorithm according to “Castano” (1-4-7 rule) [55] and NetMHCIIpan version 3.1 [35]
- Then likelihood for presentation is given as “+” and “−” respectively; SYFPEITHI half max scores regarding MHC class I presentation are given in brackets. Mutations in the peptides are indicated by underline
- WB weak binder, SB strong binder, NB no binding predicted