Fig. 2

Structure of peptides covering neo- versus wild-type epitopes. Tumor-specific single nucleotide polymorphisms (orange) identified with NGS technology in the proteins RMI1 and KIF4B. Two 9-mer peptides were designed per tumor specific SNP, each peptide spanning the respective mutated sequence, yet varying at the N-terminus. Structural differences between normal (yellow) and tumor specific peptide (blue) are shown in 3D, generated with IMTEC and UCSF chimera