Table 2 Lipid profile, non-cholesterol sterols and Achilles tendon thickness of subjects without or with xanthomas
FH | |||
|---|---|---|---|
Subjects without xanthomas n = 63 | Subjects with xanthomas n = 40 | p | |
Total cholesterol, mg/dl | 308.8 ± 48.2 | 354.9 ± 63.1 | < 0.001 |
Triglycerides, mg/dl | 93 (66–149) | 98 (65–175) | 0.707 |
HDL cholesterol, mg/dl | 51.9 ± 15.7 | 54.9 ± 16.4 | 0.369 |
Non-HDL cholesterol, mg/dl | 256.8 ± 47.3 | 300.1 ± 62.0 | < 0.001 |
LDL cholesterol, mg/dl | 235.4 ± 51.6 | 274 ± 55.0 | 0.001 |
Apolipoprotein A1, mg/dl | 148.6 ± 34.8 | 143.4 ± 31.8 | 0.450 |
Apolipoprotein B, mg/dl | 172.5 ± 31.4 | 191.4 ± 48.1 | 0.019 |
Maximum Achilles tendon thickness, mm | 4.70 (4.43–4.95) | 5.71 (5.30–6.88) | < 0.001 |
Mean Achilles tendon thickness, mm | 4.51 (4.16–4.73) | 5.49 (5.05–6.63) | < 0.001 |
Cholesterol HPLC–MS/MS, mg/dl | 314.6 ± 52.1 | 351.4 ± 73.1 | 0.004 |
5α-cholestanol, mg/dl | 0.665 ± 0.269 | 0.843 ± 0.375 | 0.006 |
β-sitosterol, mg/dl | 0.602 ± 0.319 | 0.767 ± 0.462 | 0.034 |
Campesterol, mg/dl | 0.329 ± 0.173 | 0.384 ± 0.230 | 0.176 |
Stigmasterol, mg/dl | 0.0462 ± 0.0296 | 0.0528 ± 0.0287 | 0.269 |
Sitostanol, mg/dl | 0.0217 (0.0093–0.0551) | 0.0338 (0.0119–0.0565) | 0.614 |
Desmosterol, mg/dl | 0.773 ± 0.345 | 0.896 ± 0.430 | 0.109 |
Lanosterol, mg/dl | 0.820 ± 0.383 | 0.896 ± 0.430 | 0.566 |
24S-hydroxycholesterol, mg/dl | 0.0100 ± 0.0042 | 0.0115 ± 0.0061 | 0.142 |
27-hydroxycholesterol, mg/dl | 0.0163 (0.0117–0.0210) | 0.0167 (0.0123–0.0270) | 0.161 |
7α-hydroxy-4-cholesten-3-ona, mg/dl × 10 | 0.0370 (0.0253–0.0542) | 0.0358 (0.0242–0.0511) | 0.735 |