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Table 2 Lipid profile, non-cholesterol sterols and Achilles tendon thickness of subjects without or with xanthomas

From: Association between non-cholesterol sterol concentrations and Achilles tendon thickness in patients with genetic familial hypercholesterolemia

  FH
Subjects without xanthomas
n = 63
Subjects with xanthomas
n = 40
p
Total cholesterol, mg/dl 308.8 ± 48.2 354.9 ± 63.1 < 0.001
Triglycerides, mg/dl 93 (66–149) 98 (65–175) 0.707
HDL cholesterol, mg/dl 51.9 ± 15.7 54.9 ± 16.4 0.369
Non-HDL cholesterol, mg/dl 256.8 ± 47.3 300.1 ± 62.0 < 0.001
LDL cholesterol, mg/dl 235.4 ± 51.6 274 ± 55.0 0.001
Apolipoprotein A1, mg/dl 148.6 ± 34.8 143.4 ± 31.8 0.450
Apolipoprotein B, mg/dl 172.5 ± 31.4 191.4 ± 48.1 0.019
Maximum Achilles tendon thickness, mm 4.70 (4.43–4.95) 5.71 (5.30–6.88) < 0.001
Mean Achilles tendon thickness, mm 4.51 (4.16–4.73) 5.49 (5.05–6.63) < 0.001
Cholesterol HPLC–MS/MS, mg/dl 314.6 ± 52.1 351.4 ± 73.1 0.004
5α-cholestanol, mg/dl 0.665 ± 0.269 0.843 ± 0.375 0.006
β-sitosterol, mg/dl 0.602 ± 0.319 0.767 ± 0.462 0.034
Campesterol, mg/dl 0.329 ± 0.173 0.384 ± 0.230 0.176
Stigmasterol, mg/dl 0.0462 ± 0.0296 0.0528 ± 0.0287 0.269
Sitostanol, mg/dl 0.0217 (0.0093–0.0551) 0.0338 (0.0119–0.0565) 0.614
Desmosterol, mg/dl 0.773 ± 0.345 0.896 ± 0.430 0.109
Lanosterol, mg/dl 0.820 ± 0.383 0.896 ± 0.430 0.566
24S-hydroxycholesterol, mg/dl 0.0100 ± 0.0042 0.0115 ± 0.0061 0.142
27-hydroxycholesterol, mg/dl 0.0163 (0.0117–0.0210) 0.0167 (0.0123–0.0270) 0.161
7α-hydroxy-4-cholesten-3-ona, mg/dl × 10 0.0370 (0.0253–0.0542) 0.0358 (0.0242–0.0511) 0.735
  1. Values are mean ± SD or median (interquartile range). P refers to differences calculated by Student’s t test for data normally distributed and Mann–Whitney U test for skewed data
  2. LDL denotes low density lipoprotein; HDL, high density lipoprotein; HPLC–MS/MS, high performance liquid chromatography tandem mass spectrometry