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Table 2 Performance characteristics of Tetraplex system with reference to QMVR for identification of MMR-deficient CRCs in the test set

From: Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

No. of markers displaying allelic variation The Tetraplex marker panel
Sensitivity (%) Specificity (%) PPV (%) NPV (%)
4 88.6 (81.1–93.3) 100 (98.2–100) 100 (96.0–100) 94.6 (90.9–96.9)
3 95.2 (89.3–97.9) 100 (98.2–100) 100 (96.3–100) 97.7 (94.7–99.0)
2 96.2 (90.6–98.5) 100 (98.2–100) 100 (96.4–100) 98.1 (95.3–99.3)
1 97.1 (91.9–99.0) 95.3 (91.5–97.4) 91.1 (84.3–95.1) 98.6 (95.8–99.5)
  1. Results are expressed as percentages (%), with 95% confidence intervals in parentheses
  2. PPV positive predictive value, NPV negative predictive value