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Table 1 Performance characteristics of each MSI marker for the identification of MMR-deficient CRCs in the test set (317 CRCs)

From: Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

Marker References Sensitivity% (95% CI) Specificity% (95% CI) for pMMR PPV% (95% CI) for dMMR NPV% (95% CI) for pMMR
CAT25 QMVR (106–108 bp) for dMMR (n = 105) 94.3 (88.1–97.4) 100.0 (98.2–100) 100 (96.3–100) 97.3 (94.1–98.7)
dMLH1 (n = 45) 93.3 (82.1–97.7)
dMSH2 (n = 45) 100 (92.1–100)
dMSH6 (n = 15) 80.0 (54.8–93.0)
NR21 QMVR (131–134 bp) for dMMR (n = 105) 91.4 (84.5–95.4) 99.5 (97.4–99.9) 99.0 (94.3–99.8) 95.9 (92.4–97.8)
dMLH1 (n = 45) 95.6 (85.2–98.8)
dMSH2 (n = 45) 97.8 (88.4–99.6)
dMSH6 (n = 15) 60.0 (35.7–80.2)
NR27 QMVR (153–156 bp) for dMMR (n = 105) 94.3 (88.1–97.4) 97.6 (94.6–99.0) 95.2 (89.2–97.9) 97.2 (94.0–98.7)
dMLH1 (n = 45) 95.6 (85.2–98.8)
dMSH2 (n = 45) 100 (92.1–100)
dMSH6 (n = 15) 73.3 (48.0–89.1)
BAT26 QMVR (175–177 bp) for dMMR (n = 105) 95.2 (89.3–97.9) 98.1 (95.2–99.3) 96.2 (90.5–98.5) 97.7 (94.6–99.0)
dMLH1 (n = 45) 97.8 (88.4–99.6)
dMSH2 (n = 45) 100 (92.1–100)
dMSH6 (n = 15) 73.3 (48.0–89.1)
  1. PPV positive predictive value, NPV negative predictive value