Table 1 Performance characteristics of each MSI marker for the identification of MMR-deficient CRCs in the test set (317 CRCs)

CAT25

QMVR

(106–108 bp)

for dMMR (n = 105)

94.3 (88.1–97.4)

100.0 (98.2–100)

100 (96.3–100)

97.3 (94.1–98.7)

dMLH1 (n = 45)

93.3 (82.1–97.7)

dMSH2 (n = 45)

100 (92.1–100)

dMSH6 (n = 15)

80.0 (54.8–93.0)

NR21

QMVR

(131–134 bp)

for dMMR (n = 105)

91.4 (84.5–95.4)

99.5 (97.4–99.9)

99.0 (94.3–99.8)

95.9 (92.4–97.8)

dMLH1 (n = 45)

95.6 (85.2–98.8)

dMSH2 (n = 45)

97.8 (88.4–99.6)

dMSH6 (n = 15)

60.0 (35.7–80.2)

NR27

QMVR

(153–156 bp)

for dMMR (n = 105)

94.3 (88.1–97.4)

97.6 (94.6–99.0)

95.2 (89.2–97.9)

97.2 (94.0–98.7)

dMLH1 (n = 45)

95.6 (85.2–98.8)

dMSH2 (n = 45)

100 (92.1–100)

dMSH6 (n = 15)

73.3 (48.0–89.1)

BAT26

QMVR

(175–177 bp)

for dMMR (n = 105)

95.2 (89.3–97.9)

98.1 (95.2–99.3)

96.2 (90.5–98.5)

97.7 (94.6–99.0)

dMLH1 (n = 45)

97.8 (88.4–99.6)

dMSH2 (n = 45)

100 (92.1–100)

dMSH6 (n = 15)

73.3 (48.0–89.1)