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Table 2 Univariate and multivariate cox regression analyses for recurrence free survival

From: Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma

Risk factors Univariate analysis Multivariate analysis
HR P value 95% CI HR P value 95% CI
MEG3 methylation 3.624 0.040 1.060–12.389 4.639 0.021 1.260–17.087
IIRC stage (A/B/C/D, E) 17.901 < 0.001 5.195–61.678 7.579 0.018 1.418–40.511
Nodal or distant metastasis (negative, positive) 12.174 < 0.001 4.725–31.369 4.247 0.008 1.466–12.303
Optic nerve invasion (negative, positive) 13.988 < 0.001 4.072–48.045 2.406 0.314 0.436–13.279
  1. HR hazard ratio