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Table 3 CNVs in TP53, BRCA1, BRCA2, ERBB2, IDH1, and IDH2

From: Comprehensive molecular biomarker identification in breast cancer brain metastases

Case

Copy number state

No. of OMIM genes1

Important cancer genes

Array nomenclature2

Jed81_MT

Mosaic-loss

226

TP53

arr[hg19] 17p13.3p11.2(525-20,011,122)x1-2

Jed82_MT

Mosaic-loss

291

TP53

arr[hg19] 17p13.3q12(525-32,273,420)x1-2

Jed89_MT

Mosaic-loss

289

TP53

arr[hg19] 17p13.3q11.2(525-31,245,235)x1-2

Jed82_MT

Loss

6

BRCA1

arr[hg19] 17q21.31(41,251,930-41,829,105)x1

Jed81_MT

Gain

5

BRCA2

arr[hg19] 13q13.1q13.2(32,960,791-34,576,864)x3

Jed89_MT

Mosaic-loss

103

BRCA2

arr[hg19] 13q11q14.2(19,436,286-47,693,486)x1-2

Jed82_MT

Gain

23

ERBB2

arr[hg19] 17q12q21.1(37,063,504-38,179,492)x4

Jed81_MT

Mosaic-loss

435

IDH1

arr[hg19] 2q14.3q37.3(123,839,696-242,275,944)x1-2

Jed82_MT

Mosaic-loss

75

IDH1

arr[hg19] 2q32.3q35(192,641,695-216,741,600)x1-2

Jed89_MT

Gain

11

IDH2

arr[hg19] 15q26.1(90,592,464-91,543,761)x4

  1. 1OMIM, online mendelian inheritance in man; 2on average 91% overlap of affected regions between duplicate assays