Fig. 7

A merged network based on eight upstream regulators, of which E2f, ERBB2, IL6, HGF, and RABL6 were in a predicted activation state (z-score > 2) and let-7, TP53, and CDKN2A were in a predicted inhibition state (z-score < - 2). P-value of overlap for all upstream regulators is < 0.0029. The network is based on the list of 370 differentially expressed probe sets and displays the expression values derived from the comparison group BCBM vs. prBT (Additional file 1). Upregulated molecules include ANGPTL4, ANLN, BCL3, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCNE2, CCNG1, CDC25A, CDC45, CDCP1, CEBPB, CKS2, DKC1, DTYMK, E2F1, FGG, KIF15, KIF24, LBP, LRP8, MYCN, NUSAP1, ORC1, PCLAF, PFKP, RAD51, RDH10, RFC4, S100A7, S100A9, TTK, VDR, WASF3, and WDR76. Downregulated molecules include CYBB, DRAM1, DUSP1, FZD7, GJA1, JAK2, KITLG, LY86, NR3C1, PLAZG16, PLK2, POLR3GL, PPF1BP1, RARRES2, SSPN, TRIM22, and ZNF655. Asterisk marks molecule with more than one probe set. The pathway was overlaid with the Molecule Activity Predictor to precalculate further molecular effects, as outlined in the prediction legend