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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Comprehensive molecular biomarker identification in breast cancer brain metastases

Fig. 6

The top three merged networks based on the 370 probe sets comprise molecules related to cell cycle, DNA replication, recombination, and repair, cellular assembly and organization, connective tissue and developmental disorders, gastrointestinal and inflammatory disease and inflammatory response (Table 2). Expression values are derived from the comparison group BCBM vs. BC (Additional file 1). Upregulated molecules include ANLN, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCDC6, CDC25A, CDC45, CENPU, CEP72, CHRNA5, CKS2, DDT, DGKD, DMBT1, E2f, E2F1, EIF4EBP1 (alias 4EBP1), ESRP2, EXOSC4, GPR26, GSDMB, HN1, LLGL2, KNL1 (CASC5), MYCN, NUSAP1, ORC1, PFKP, RAD51, RAD54L, RAP1GAP, RASGRF1, RDH10, RRAGD, RPL13A (SNORD34, SNORD35A), RPLP2 (SNORA52), RPS2 (SNORA10), RSP3 (SNORD15A), S100A7, S100A7A, S100A9, SGO1 (SGOL1), SLC25A19, SPRY4, SRCIN1, STK3, TBX20, TRIB3, TTK, UBE2S, and XRCC2. Downregulated molecules include CCNG1, CDON, CEP120, CLK1, DHRS3, EID1, FGD6, HPS5, HSD17B4, KNOP1, LRCH2, MICU3, NR3C1, NUMBL, PDGFRL, PDLIM5, PLK2, SMARCA1, SPG20, TP53I3, and TTC21B. Integrative network molecules comprise Akt, AMPK, APC (complex), CD3, CDK4/6, Cyclin A, Cyclin B, Cyclin D, Cyclin E, E2f, EGLN, ERK1/2, Fanc, Focal adhesion kinase (FAC), Gpcr, Histone h4, IL17R, JUN/JUNB/JUND, NFkB (complex), Notch, nucleoside-triphosphatase, Ppp2c, Rb, RPA, S100, and Ubiquitin. Of notice, key nodes as Akt, ERK1/2, NFkB, and Ras were in a predicted activation stage. Asterisks mark molecules with more than one probe set. The pathway was overlaid with the Molecule Activity Predictor to precalculate further molecular effects, as outlined in the prediction legend

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