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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model

Fig. 2

Inflammation induced by ethanol in NSG mice reconstituted with PBMC from UC patients is characterized by subtypes of monocytes, macrophages, effector memory CD8+ cells and by Mtarc, mTGFß1 and HGF. a Flow cytometric analysis of subtypes of CD14+ monocytes and CD11b+ macrophages of human leukocytes isolated from spleens. Unchallenged control group (control), group challenged with 10% ethanol at day 8 and 50% ethanol at days 15 and 18 (ethanol). For complete data set see Additional file 1: Table S3). Labels given on x-axes on the bottom row apply to all charts. b Correlation analysis of effector memory CD8+ T-cells with clinical activity score and Th17 T-cells depicted as scatter blots. Numbers indicate Spearman rank-order correlation coefficients (rho) and p values. Sample sizes: clinical score n = 29, Th17 n = 25. c mRNA expression analysis of mTARC, mTGFß1 and HGF depicted as boxplots. Lg-delta CT, logarithmic delta cycle threshold. Boxes represent upper and lower quartiles. Whiskers represent variability and outliers are plotted as individual points. For comparison of unchallenged control group versus challenged group, a Student T-test was conducted. Labels given on x- and y-axes on the bottom and the side row apply to all charts

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