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Table 4 Mean plasma water T2 values for conditions and measures associated with early metabolic syndrome

From: Water T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study

Conditions and measuresa

Cutoff value

Mean plasma T2 (ms) ± S.E.

No

Yes

Δb

Odds ratiob

Hyperinsulinemia (H)

Any of 3 below

796.1 ± 7.9

728.7 ± 8.4

67.4****

9.5 (2.9–32.5)****

 High fasting insulinc

≥ 10.0 μIU/mL

786.6 ± 7.4

721.7 ± 10.2

65.0****

 

 High insulin C-peptidec

≥ 2.3 mg/mL

780.7 ± 8.0

733.1 ± 11.1

47.6***

 

 Low McAuley Indexd

≤ 6.07

778.1 ± 7.2

718.1 ± 13.3

60.0***

 

Dyslipidemia (D)

Any of 3 below

798.1 ± 8.6

734.3 ± 8.1

63.8****

5.8 (2.3–15.6)****

 High non-HDL-Cc

≥ 149 mg/dL

782.4 ± 7.9

729.8 ± 10.9

52.6***

 

 Small, dense LDL

Pattern B/AB

778.0 ± 8.1

736.4 ± 11.6

41.6**

 

 High LDL-Pc

≥ 1408 nM

779.1 ± 8.0

734.2 ± 11.5

44.9**

 

Inflammation (I)e

Any of 3 below

808.3 ± 9.4

738.4 ± 7.3

69.9****

10.4 (3.2–35)****

 High CRPc

≥ 2.5 mg/L

778.4 ± 7.6

725.1 ± 12.9

53.2***

 

 High WBC countc

≥ 6.92 × 103/μL

780.3 ± 8.3

737.3 ± 10.8

43.0**

 

 High serum globulinsc

≥ 2.9 g/dL

788.5 ± 7.7

725.8 ± 9.7

62.7****

 

Electrolyte abnormal

Any of 3 below

784.8 ± 10.3

747.3 ± 8.8

37.5**

1.6 (1.1–2.3)*

 Low (Cl− + CO2)f

≤ 126 meq/L

776.5 ± 9.0

745.6 ± 10.3

30.8*

 

 High anion gapc

≥ 17.8 meq/L

777.8 ± 7.9

731.6 ± 11.6

46.2**

 

 High anion gap corr.g

≥ 17.7 meq/L

776.8 ± 8.1

742.0 ± 11.3

34.8*

 

Metabolic syndrome

Ref. [4]

776.0 ± 7.4

721.6 ± 14.1

54.5**

2.7 (1.2–5.9)**

H + ≥ 1 other condition

See above

796.8 ± 7.6

725.8 ± 8.3

71.1****

15 (4–63)****

H + ≥ 2 other conditions

See above

792.6 ± 6.9

716.5 ± 9.0

76.1****

17 (4–73)****

H + D + I

See above

786.5 ± 6.5

705.0 ± 10.6

81.4****

24 (5–-124)****

  1. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001
  2. aThis analysis included variables collected in both Phase 1 and Phase 2 of this study (n = 72)
  3. bMean difference (Δ) and odds ratio (95% confidence limits) for the mean difference shown one column to the left
  4. cTop tertile of subjects in this study
  5. dObtained using formula in abstract of ref [26], with insulin = 12.2 μIU/mL and triglyceride = 1.5 mM as input
  6. eFor this row, the Welch test was used in place of the t test, as equal variances could not be confirmed
  7. fTotal measured anions, where ~ 95% of total CO2 is HCO3 −; bottom tertile of subjects in this study
  8. gAnion gap corrected for albumin concentration using regression residuals; top tertile of subjects in this study