Fig. 7

Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances chemotherapeutic resistance of CRC cells. a c-Myc overexpression enhanced the resistance of SW480 cells to oxaliplatin, while the enhanced effect was dampened by miR-200b-3p partly. b miR-200b-3p overexpression reduced the resistance of LoVo cells to oxaliplatin, while the reduced effect was reversed by nontargetable PRDX2 partly. c c-Myc overexpression repressed oxaliplatin-induced apoptosis in SW480 cells, while the repressive effect was reversed by miR-200b-3p partly. d miR-200b-3p overexpression enhanced oxaliplatin-induced apoptosis in LoVo cells, while the enhanced effect was abolished by nontargetale PRDX2 partly. e, f The oxaliplatin-induced apoptosis was statistically analyzed in LoVo cells (e) or in SW480 cells (f) among different treatment groups