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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer

Fig. 6

Expression profiles of c-Myc, miR-200b-3p and PRDX2 in CRC tissue samples and their clinical significances. a c-Myc protein expression profile was detected by IHC in paraffin-embedded CRC tissue samples (n = 97). a1 The expression levels of c-Myc in adjacent normal colon mucosa (×100, ×200). a2 The expression levels of c-Myc in intramucosal carcinoma and normal colon mucosa (×100, ×400). a3 The expression levels of c-Myc in submucosa carcinoma and normal colon mucosa (×100, ×200). a4 The expression levels of c-Myc in carcinoma infiltrated vessel of muscular layer (×100, ×400). a5 The expression levels of c-Myc in carcinoma infiltrated serosa layer (×100, ×400). b PRDX2 protein expression profile was detected by IHC in paraffin-embedded CRC tissue samples (n = 97). b1 The expression levels of PRDX2 in adjacent normal colon mucosa (×100, ×200). b2 The expression levels of PRDX2 in submucosa carcinoma and normal colon mucosa (×100, ×200). b3 The expression levels of PRDX2 in intramucosal carcinoma and normal colon mucosa (×100, ×200). b4 The expression levels of PRDX2 in carcinoma infiltrated muscular layer (×100, ×200). b5 The expression levels of PRDX2 in carcinoma with moderate-differentiation (lower) and poor-differentiation (upper) (×50, ×100). b6 The expression levels of PRDX2 in carcinoma infiltrated muscular layer (upper) and subserosa layer (lower) (×100, ×200). b7 The expression levels of PRDX2 in carcinoma infiltrated vessel of muscular layer (×100, ×400). b8 The expression levels of PRDX2 in carcinoma infiltrated serosa layer (×100, ×200). c, d Kaplan-Meier survival analysis for CRC patients with c-Myc score (0, 1) and (2, 3) (c) or PRDX2 score (0, 1) and (2, 3) (d). e Relative miR-200b-3p expression profile was detected by qPCR in paired fresh CRC tissue samples (n = 97). The miR-200b-3p expression of each CRC tissue was normalized to that of the PNCM tissue (***p < 0.001). f Kaplan–Meier survival analysis for CRC patients with high and low miR-200b-3p expression

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